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Volume 33, Nº 4, July and August 2020


DOI: https://doi.org/10.36660/ijcs.202000164


Heart Failure with Preserved Ejection Fraction and COVID-19: a Pernicious Relationship

Evandro Tinoco Mesquita

Antonio Jose Lagoeiro Jorge

Humberto Villacorta

Luiz Claudio Danzmann

Wolney de Andrade Martins

Figure 1 – Pathophysiological mechanisms of myocardial injury in COVID-19 and its relationship with HFpEF and comorbidities.


The ongoing pandemic of Severe Acute Respiratory Virus-2 (SARS-CoV2) infection was first recognized in China in 2019 and brought significant health and economic threats around the world. On January 31, 2020, the World Health Organization (WHO) declared the disease caused by SARS-CoV2 an international public health emergency and on March 11, 2020, the WHO declared it a pandemic.1,2 Three months after the initial WHO declaration, there are more than 5 million confirmed cases worldwide and 300,000 deaths. In Brazil, in the same time interval, there were more than 850,000 cases and 43,000 deaths, with an upward trend.3

Keywords: Cardiovascular Diseases/complications; Heart Failure/ complications; Stroke Volume; Coronavirus; COVID-19; Pandemics; Mortality; Pneumonia.