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Volume 33, Nº 4, July and August 2020


DOI: https://doi.org/10.36660/ijcs.20190116


Electrocardiographic Abnormalities in Hypertension Models

Ana Gabriela Conceição-Vertamatti

Filipy Borghi

Larissa Yuri Ishizu

Gustavo Trevisan Costa

Luiz Alberto Ramos

Miguel Arcanjo Areas

Dora Maria Grassi-Kassisse

Dr. Ana Gabriela Conceição-Vertamatti


Background: Hypertensive condition can lead to abnormalities in heart structure and electrical activity. The electrocardiogram (ECG) is a recording of the electrical activity of the heart and widely used to diagnose and detect heart problem.

Objective: We conducted a comparative ECG analysis between two hypertension models (L-NAME and SHR) and their controls (Wistar and Wistar-Kyoto) at six and 15th week of age.

Methods: Blood pressure was measured at the end of the 15th week, and electrocardiography was performed at six and 15 weeks of age in anaesthetized rats. Data normality was confirmed by Kolmogorov-Smirnov test followed by unpaired Student’s t-test and the Mann-Whitney for parametric and non-parametric data, respectively. Results are expressed as mean ± SD. The accepted level of significance was set at p < 0.05.

Results: L-NAME exhibited prolongation of JT and QT intervals and SHR showed a decrease in heart rate when compared to Wistar-Kyoto and L-NAME. Wistar-Kyoto exhibited short PR interval with increased QRS complex, and only QT prolongation at 15 weeks compared to Wistar.

Conclusions: All the hypertension models used in this study featured an increase in blood pressure. However, while SHR showed cardiac dysfunction, L-NAME exhibited changes in ventricular performance. These results may guide future studies on different types and models of hypertension. (Int J Cardiovasc Sci. 2020; 33(4):321-328)

Keywords: Rats; Hypertension; Blood Pressure; Electrocardiography/methods; NG-Nitroarginine Methil Éster/ adverse effects; Rats, Inbred (SHR).