Volume 33, Nº 1, January and february 2020
DOI: http://www.dx.doi.org/10.5935/2359-4802.20190025
CASE REPORT
A Rare Case of Cardiorespiratory Arrest after Metoclopramide Infusion
Cássio Alexandre Oliveira Rodrigues
Eduardo Queiroz da Cunha
Priscila Ribeiro de Paula
Rand Randall Martins
Commonly used as an antiemetic and prokinetic agent, especially in critically-ill patients to reverse gastroparesis and increase in gastric emptying, metoclopramide use can result in important adverse reactions, leading the European Medicines Agency to recommend its use at minimum doses and for a short period of time, due to the risk of neurotoxicity.1 Although often associated to neurological events, reactions to this drug affecting the cardiovascular system are less frequent when compared to those that affect the central nervous system. There have been reports of total atrioventricular block2 and sinus arrest,3 but the occurrence of metoclopramide-induced cardiorespiratory arrest (CRA) is a rare and poorly described event. Considering the scarcity of reports and its widespread use in health services, we described a case of CRA in a 21-yearold young woman immediately after the administration of metoclopramide for the treatment of diabetic gastroparesis. This report was approved by the Research Ethics Committee of HUOL (CAAE: 73091717.0.0000.5292). The free and informed consent form was signed by the patient.
Keywords: Metaclopramide/Adverse effects; Drug Prescriptions/standards; Heart Arrest; Pharmacokinetics; Drug Related Side Effects and Adverse Reactions.
