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Volume 32, Nº 2, March and April 2019


DOI: http://www.dx.doi.org/10.5935/2359-4802.20190005


Cardiac Magnetic Resonance and Amyloidosis: Review

Vaneza Ferreira Ribeiro

Diogo Costa Leandro de Oliveira

Daniel Gama das Neves

Nágela Simão Vinhosa Nunes

Humberto Villacorta Junior

Marcelo Souto Nacif


Amyloidosis is a disease caused by extracelular deposition of insoluble protein fibrils, that results in changes in tissue architecture and consequently modification of the organ structure. Cardiac involvement is common in amyloidosis. Two major types of systemic amyloidosis affect the myocardium – immunoglobulin light chain and transthyretin amyloidosis – each leading to different prognosis. Early detection and diagnosis of cardiac amyloidosis are the main objectives in the assessment of the disease. New techniques of magnetic resonance imaging have minimized the need for biopsies for the diagnosis. Late gadolinium enhancement technique, and more recently T1 mapping, have allowed a simplified evaluation of amyloid deposits and extracellular volume. The aim of this review was to describe basic concepts and updates of the use of magnetic resonance imaging for the diagnosis amyloidosis and evaluation of its severity.

Keywords: Amyloidosis; Myocarditis/pathology; Plaque, Amyloid/diagnostic imaging; Magnetic Resonance Imaging.