Brugada Pattern, Brugada Phenocopy, What to Think?
José Luis Martins
Propafenone is a class 1 anti-arrhythmic medication with beta-adrenergic and calcium channel blocker properties. Brugada syndrome (BrS) has a typical electrocardiographic pattern characterized by increased propensity for malignant ventricular arrhythmias and sudden death in patients with no structural heart disease. Brugada phenocopies (BrP) have electrocardiographic patterns that are identical to true type 1 and type 2 Br, despite the absence of a true congenital BrS. BrP are elicited by clinical conditions including ionic (or water and electrolyte) disturbances, myocardial ischemia and pulmonary embolism. We report a case of suicide attempt by an overdose of propafenone which yielded a type 1 Brugada pattern.
Keywords: Brugada syndrome/genetic; Propafenone; Anti-Arrhythmia Agents; Suicide; Death, Sudden, Cardiac; Arrhythmias, Cardiac; Electrocardiography.