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Volume 114, Nº 1, January 2020


DOI: https://doi.org/10.36660/abc.20180140


Euterpe Oleracea Mart. (Açaí) Reduces Oxidative Stress and Improves Energetic Metabolism in Myocardial Ischemia-Reperfusion Injury in Rats

Patricia Alegre

Livia Mathias

Maria Angelica Lourenço

Priscila Portugal dos Santos

Andrea Gonçalves

Ana Angélica Fernandes

Paula Schmidt Azevedo Gaiolla

Marcos Ferreira Minicucci

Leonardo Zornoff

Sergio Alberto Rupp Paiva

Bertha Furlan Polegato


Background: Euterpe oleracea Mart. (açaí) is a fruit with high antioxidant capacity and could be an adjuvant strategy to attenuate ischemia-reperfusion injury.

Objective: To evaluate the influence of açaí in global ischemia-reperfusion model in rats.

Methods: Wistar rats were assigned to 2 groups: Control (C: receiving standard chow; n = 9) and Açaí (A: receiving standard chow supplemented with 5% açaí; n = 10). After six weeks, the animals were subjected to the global ischemia-reperfusion protocol and an isolated heart study to evaluate left ventricular function. Level of significance adopted: 5%.

Results: There was no difference between the groups in initial body weight, final body weight and daily feed intake. Group A presented lower lipid hydroperoxide myocardial concentration and higher catalase activity, superoxide dismutase and glutathione peroxidase than group C. We also observed increased myocardial activity of β-hydroxyacyl coenzyme-A dehydrogenase, pyruvate dehydrogenase, citrate synthase, complex I, complex II and ATP synthase in the A group as well as lower activity of the lactate dehydrogenase and phosphofructokinase enzymes. The systolic function was similar between the groups, and the A group presented poorer diastolic function than the C group. We did not observe any difference between the groups in relation to myocardial infarction area, total and phosphorylated NF-κB, total and acetylated FOXO1, SIRT1 and Nrf-2 protein expression.

Conclusion: despite improving energy metabolism and attenuating oxidative stress, açai supplementation did not decrease the infarcted area or improve left ventricular function in the global ischemia-reperfusion model. (Arq Bras Cardiol. 2020; 114(1):78-86)

Keywords: Euterpe Olerácea; Oxidative Stress; Energy Metabolism; Chemical Reactions; Myocardial Ischemia; Myocardial Reperfusion Injury; Rats.