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Volume 114, Nº 1, January 2020

   

DOI: https://doi.org/10.36660/abc.20190111

REVIEW ARTICLE

Pathophysiology and Treatment of Heart Failure with Preserved Ejection Fraction: State of the Art and Prospects for the Future

Sara Lopes Fernandes

Rita Ribeiro Carvalho

Luís Graça Santos

Fernando Montenegro Sá

Catarina Ruivo

Sofia Lázaro Mendes

Hélia Martins

João Araujo Morais



Figure 1 – Pathophysiology of HFpEF - possible mechanisms involved. AF: atrial fibrillation; CAD: coronary artery disease; CKD: chronic kidney disease; COPD: chronic obstructive pulmonary disease; HFpEF: heart failure with preserved ejection fraction; HT: arterial hypertension; NO-cGMP-PKG: nitric oxide, reduced cyclic guanosine monophosphate and protein kinase G; PH: pulmonary hypertension; RAAS: renin-angiotensin-aldosterone system; RV: right ventricle.





Keywords: Heart Failure/physiopathology; Heart Failure/diagnosis; Heart Failure/drug therapy; Systolic Volume; Heart Failure/ complications.










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2. Cardiovascular Disease in Portuguese-speaking Countries
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3. Practices in Myocardial Perfusion Scintigraphy
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5. MMP-9 Levels and IMT of Carotid Arteries are Elevated in Obese Children and Adolescents Compared to Non-Obese
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Comitê Coordenador da Diretriz de Insuficiência Cardíaca

2 - Statement on Antiplatelet Agents and Anticoagulants in Cardiology - 2019
Carlos V. Serrano Jr., Alexandre de M. Soeiro et al.

3 - Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Guideline Update of the Brazilian Society of Cardiology - 2019
Claudia Bernoche, Sergio Timerman et al.

4 - Updated Cardiovascular Prevention Guideline of the Brazilian Society of Cardiology - 2019
Dalton Bertolim Précoma, Gláucia Maria Moraes de Oliveira et al.

5 - Position Statement on Indications of Echocardiography in Adults - 2019
Silvio Henrique Barberato, Minna Moreira Dias Romano at al.

6 - Atherosclerotic Plaque in Patients with Zero Calcium Score at Coronary Computed Tomography Angiography
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2. Subclinical Thyroid Dysfunction was not Associated with Cardiac Arrhythmias in a Cross-Sectional Analysis of the ELSA-Brasil Study
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3. A Proposed Inflammatory Score of Circulating Cytokines/Adipokines Associated with Resistant Hypertension, but Dependent on Obesity Parameters
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4. Changes in Cardiac Autonomic Modulation in Women with Breast Cancer Using Aromatase Inhibitors and the Relation with Biochemical Variables
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5. PCSK9 Inhibitors: Clinical Relevance, Molecular Mechanisms, and Safety in Clinical Practice
Filipe Ferrari, Ricardo Stein et al.


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