Effects of Physical Training on the Myocardium of Oxariectomized LDLr Knockout Mice: MMP 2/9, Collagen I/III, Inflammation and Oxidative Stress
Flávia de Sousa Gehrke
Fernando Luiz Affonso Fonseca
Beatriz da Costa Aguiar Alves
Luiz Vinicius de Alcantara Sousa
Laura Beatriz Mesiano Maifrino
Background: The emergence of coronary heart disease is increased with menopause, physical inactivity and with dyslipidemia. Physical training is known to promote the improvement of cardiovascular functions.
Objective: To investigate the effects of aerobic physical training on the left ventricle in ovariectomized LDL knockout mice.
Methods: Thirty animals were divided into 6 groups (n = 5): Sedentary non-ovariectomized control; Sedentary ovariectomized control; Trained ovariectomized control; Sedentary non-ovariectomized LDL-knockout, sedentary ovariectomized LDL-knockout and trained ovariectomized LDL-knockout. We analyzed the average parameters of apparent density of collagen fibers types I and III, and metalloproteinase type 2 and type 9, were considered significant p < 0.05.
Results: The results showed that the proposed exercise protocol altered the volume of type I collagen fibers, altered collagen remodeling parameters (MMP-2), and also reduced the 8-hydroxy-2’-deoxyguanosine (8OHdG) oxidative stress parameter.
Conclusion: Moderate intensity aerobic training acts on collagen fiber volume, on collagen remodeling with the reduction of oxidative stress in the left ventricles of ovariectomized LDL-knockout mice. (Arq Bras Cardiol. 2020; 114(1):100-105)
Keywords: Coronary Artery Disease; Exercise; Menopause; Dyslipidemias; Motor Activity; Collagen; Oxidative Stress; Inflammation; Mice.