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Volume 112, Nº 4, April 2019

   

DOI: http://www.dx.doi.org/10.5935/abc.20190029

REVIEW ARTICLE

PCSK9 Inhibitors: Clinical Relevance, Molecular Mechanisms, and Safety in Clinical Practice

Filipe Ferrari

Ricardo Stein

Marcelo Trotte Motta

Emilio Hideyuki Moriguchi

Dr. Filipe Ferrari







Figure 1 – Mechanisms of PCSK9 involvement in LDL metabolism.





Keywords: Cardiovascular Diseases/physiopathology; Coronary Artery Disease/mortality; Proprotein Convertase 9; Cholesterol, LDL; Lipoproteins; Anticholesteromic Agents.










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ARTICLES
1. Crocin and voluntary exercise increase heart angiogenesis through miRNA expression
Vajihe Ghorbanzadeh, Mustafa Mohammadi et al.

2. Cardiovascular Disease in Portuguese-speaking Countries
Bruno Ramos Nascimento, Luisa Campos Caldeira Brant et al.

3. Practices in Myocardial Perfusion Scintigraphy
Carlos Vitor Braga Rodrigues, Anderson Oliveira et al.

4. Heart Rate and Associated Factors in Adolescents
Diego Giulliano Destro Christofaro, Juliano Casonatto et al.

5. MMP-9 Levels and IMT of Carotid Arteries are Elevated in Obese Children and Adolescents Compared to Non-Obese
Claudio Andrade, Adriana Bosco et al.

6. Endothelial Cells, Microparticles and Runners
Celia Reginade Oliveira Bittencourt, Maria Cristina de Oliveira Izar et al.
1 - Brazilian Guideline for Chronic and Acute Heart Failure
Comitê Coordenador da Diretriz de Insuficiência Cardíaca

2 - Statement on Antiplatelet Agents and Anticoagulants in Cardiology - 2019
Carlos V. Serrano Jr., Alexandre de M. Soeiro et al.

3 - Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Guideline Update of the Brazilian Society of Cardiology - 2019
Claudia Bernoche, Sergio Timerman et al.

4 - Updated Cardiovascular Prevention Guideline of the Brazilian Society of Cardiology - 2019
Dalton Bertolim Précoma, Gláucia Maria Moraes de Oliveira et al.

5 - Position Statement on Indications of Echocardiography in Adults - 2019
Silvio Henrique Barberato, Minna Moreira Dias Romano at al.

6 - Atherosclerotic Plaque in Patients with Zero Calcium Score at Coronary Computed Tomography Angiography
Fabíola Santos Gabriel, Luiz Flávio Galvão Gonçalves et al.
1. Women with Polycystic Ovarian Syndrome Exhibit Reduced Baroreflex Sensitivity That May Be Associated with Increased Body Fat
Stella Vieira Philbois, Ada Clarice Gastaldi et al.

2. Subclinical Thyroid Dysfunction was not Associated with Cardiac Arrhythmias in a Cross-Sectional Analysis of the ELSA-Brasil Study
Kamilla Maria Araújo Brandão Rajão, Antônio Luiz Pinho Ribeiro et al.

3. A Proposed Inflammatory Score of Circulating Cytokines/Adipokines Associated with Resistant Hypertension, but Dependent on Obesity Parameters
Ana Paula de Faria, Alessandra Mileni Versuti Ritter et al.

4. Changes in Cardiac Autonomic Modulation in Women with Breast Cancer Using Aromatase Inhibitors and the Relation with Biochemical Variables
Luana Almeida Gonzaga, Thais Reis Silva de Paulo et al.

5. PCSK9 Inhibitors: Clinical Relevance, Molecular Mechanisms, and Safety in Clinical Practice
Filipe Ferrari, Ricardo Stein et al.


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