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Volume 111, Nº 5, November 2018


DOI: http://www.dx.doi.org/10.5935/abc.20180202


Vasodilation and Reduction of Systolic Blood Pressure after One Session of High-Intensity Interval Training in Patients With Heart Failure with Preserved Ejection Fraction

Juliana Beust de Lima

Anderson Donelli da Silveira

Marco Aurélio Lumertz Saffi

Márcio Garcia Menezes

Diogo Silva Piardi

Leila Denise Cardoso Ramos Ramm

Maurice Zanini

Rosane Maria Nery

Ricardo Stein


Background: Heart failure with preserved ejection fraction (HFpEF) is a multifactorial syndrome characterized by a limited exercising capacity. High-intensity interval training (HIIT) is an emerging strategy for exercise rehabilitation in different settings. In patients with HFpEF, HIIT subacute effects on endothelial function and blood pressure are still unknown.

Objective: To evaluate the subacute effect of one HIIT session on endothelial function and blood pressure in patients with HFpEF.

Methods: Sixteen patients with HFpEF underwent a 36-minute session of HIIT on a treadmill, alternating four minutes of high-intensity intervals with three minutes of active recovery. Brachial artery diameter, flow-mediated dilation, and blood pressure were assessed immediately before and 30 minutes after the HIIT session. In all analyses, p <0.05 was considered statistically significant.

Results: There was an increase in brachial artery diameter (pre-exercise: 3.96 ± 0.57 mm; post-exercise: 4.33 ± 0.69 mm; p < 0.01) and a decrease in systolic blood pressure (pre-exercise: 138 ± 21 mmHg; post-exercise: 125 ± 20 mmHg; p < 0.01). Flow-mediated dilation (pre exercise: 5.91 ± 5.20%; post-exercise: 3.55 ± 6.59%; p = 0.162) and diastolic blood pressure (pre-exercise: 81 ± 11 mmHg; post exercise: 77 ± 8 mmHg; p = 1.000) did not change significantly. There were no adverse events throughout the experiment.

Conclusions: One single HIIT session promoted an increase in brachial artery diameter and reduction in systolic blood pressure, but it did not change flow-mediated dilation and diastolic blood pressure. (Arq Bras Cardiol. 2018; 111(5):699-707)

Keywords: Heart Failure; Arterial Pressure; Exercise; Vasodilatation; Brachial Artery; Endothelium/function