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Volume 111, Nº 5, Novembero 2018


DOI: http://www.dx.doi.org/10.5935/abc.20180215


Role of miRNAs on the Pathophysiology of Cardiovascular Diseases

Debora Cristina Pereira da Silva

Felipe Demani Carneiro

Kelly Costa de Almeida

Caroline Fernandes-Santos

Figure 1 – Synthesis of miRNA and its action on messenger RNA (mRNA). Hairpin primary-microRNAs are synthesized in the nucleus, converted into pre-miRNA by Drosha enzyme, and exported from the nucleus into the cytoplasm by the Exportin-5 protein. In the cytoplasm, pre-miRNA is recognized by the enzyme Dicer; RNA-induced silencing complex (RISC) binds to a double-stranded RNA (dsRNA), generating mature miRNA. Mature miRNA interacts with the target mRNA, leading to either its degradation or its translation.

Keywords: Cardiovascular Diseases/physiopathology; Cardiovascular Diseases/diagnosis; Cardiovascular Diseases/genetics; Biomarkers/metabolism; Cardiac, Remodeling/genetics; Atherosclerosis; MicroRNAs.