ABC | Volume 114, Nº3, Março 2020

Artigo Original Leocádio et al. Netrina-1 e IL-1 β : prognóstico na SCA Arq Bras Cardiol. 2020; 114(3):507-514 Este é um artigo de acesso aberto distribuído sob os termos da licença de atribuição pelo Creative Commons 16. FriedewaldWT, Levy RI, FredricksonDS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18(6):499-502. 17. Ramesh G, Berg A, Jayakumar C. Plasma netrin-1 is a diagnostic biomarker of human cancers. Biomarkers. 2011;16(2):172-80. 18. Link BC, Reichelt U, Schreiber M, Kaifi JT, Wachowiak R, Bogoevski D, et al. Prognostic implications of netrin-1 expression and its receptors in patients withadenocarcinoma of the pancreas.Ann SurgOncol. 2007;14(9):2591-9. 19. Harter PN, Zinke J, Scholz A, Tichy J, Zachskorn C, Kvasnicka HM, et al. Netrin-1 expression is an independent prognostic factor for poor patient survival in brain metastases. PLoS One. 2014;9(3):e92311. 20. van Gils JM, Ramkhelawon B, Fernandes L, Stewart MC, Guo L, Seibert T, et al. Endothelial expression of guidance cues in vessel wall homeostasis dysregulation under proatherosclerotic conditions. Arterioscler Thromb Vasc Biol. 2013;33(5):911-9. 21. Zhang J, Cai H. Netrin-1 prevents ischemia/reperfusion-inducedmyocardial infarction via a DCC/ERK1/2/eNOS s1177/NO/DCC feed-forward mechanism. J Mol Cell Cardiol. 2010;48(6):1060-70. 22. Mao X, Xing H, Mao A, Jiang H, Cheng L, Liu Y, et al. Netrin-1 attenuates cardiac ischemia reperfusion injury and generates alternatively activated macrophages. Inflammation. 2014;37(2):573-80. 23. Reeves WB, Kwon O, Ramesh G. Netrin-1 and kidney injury. II. Netrin-1 is an early biomarker of acute kidney injury. Am J Physiol Renal Physiol. 2008;294(4):F731-8. 24. Ramesh G, Krawczeski CD, Woo JG, Wang Y, Devarajan P. Urinary netrin-1 is an early predictive biomarker of acute kidney injury after cardiac surgery. Clin J Am Soc Nephrol. 2010;5(3):395-401. 25. Ramkhelawon B, Yang Y, van Gils JM, Hewing B, Rayner KJ, Parathath S, et al. Hypoxia induces netrin-1 and Unc5b in atherosclerotic plaques: mechanism for macrophage retention and survival. Arterioscler Thromb Vasc Biol. 2013;33(6):1180-8. 26. OzerenA,AydinM,TokacM,DemircanN,UnalacakM,GurelA,etal.Levels of serum IL-1beta, IL-2, IL-8 and tumor necrosis factor-alpha in patients with unstable angina pectoris. Mediators Inflamm. 2003;12(6):361-5. 27. Kilic T, Ural D, Ural E, Yumuk Z, Agacdiken A, Sahin T, et al. Relation between proinflammatory to anti-inflammatory cytokine ratios and long- termprognosis in patients with non-ST elevation acute coronary syndrome. Heart. 2006;92(8):1041-6. 28. Correia LC, Andrade BB, Borges VM, Clarêncio J, Bittencourt AP, Freitas R, et al. Prognostic value of cytokines and chemokines in addition to the GRACE Score in non-ST-elevation acute coronary syndromes. Clin Chim Acta. 2010;411(7-8):540-5. 29. Prabhu SD, Frangogiannis NG. The Biological Basis for Cardiac Repair After Myocardial Infarction: From Inflammation to Fibrosis. Circ Res. 2016;119(1):91-112. 30. FrantzS,Bauersachs J,ErtlG.Post-infarctremodelling:contributionofwound healing and inflammation. Cardiovasc Res. 2009;81(3):474-81. 31. Orn S, Ueland T, Manhenke C, Sandanger O, Godang K, Yndestad A, et al. Increased interleukin-1beta levels are associated with left ventricular hypertrophy and remodelling following acute ST segment elevation myocardial infarction treated by primary percutaneous coronary intervention. J Intern Med. 2012;272(3):267-76. 32. Bourgeois M M, Richards I S. Gender-specific differences in the urinary expression of aldosterone, IL-1 α and IL-1 β . Biomarkers Med. 2010;4(6):843–47. 33. Haroon J, Foureaux G, Martins A S, Ferreira A J, Reis A M, Javed Q. Gender differences in normal left ventricle of adult FVB/N mice due to variation in interleukins and natriuretic peptides expression levels. Cytokine. 2015;71(1):54-59. 34. Lyngdoh T, Marques-Vidal P, Paccaud F, Preisig M, Waeber G, Bochud M, et al. Elevated serum uric acid is associated with high circulating inflammatory cytokines in the population- based CoLaus study. PLoS ONE. 2011;6(5):e19901. 35. Marques-Vidal P, Bochud M, Bastardot F, Luscher T, Ferrero F,Gaspoz J, et al. Levels and determinants of inflammatory biomarkers in a swiss population- based sample (CoLaus study). PLoS ONE. 2011;6(6):e21002. 36. Yim J, Kim G, Lee B, Kang E S, Cha B, Kim J, et al. Relationship between circulating netrin-1 concentration, impaired fasting glucose, and newly diagnosed type 2 diabetes. Front Endocrinol. 2018;9(691). 514

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