ABC | Volume 115, Nº2, August 2020

Original Article Gatti et al. Custodiol®-HTK solution & prolonged cross-clamp time Arq Bras Cardiol. 2020; 115(2):241-250 Table 4 – Analysis of the rate of any major complication post-surgery* in different subgroups of patients with testing for interaction† Characteristic HTK cohort % MCB cohort % OR 95% CI Interaction p-Value Overall 44.1 26.5 2.19 0.79−6.08 0.132 No anaemia 33.3 25 1.5 0.34–6.7 0.391 Anaemia‡ 56.2 27.8 3.34 0.8–13.9 eGFR >85 ml/min§ 33.3 33.3 1.00 0.22–4.56 0.183 eGFR ≤85 ml/min§ 52.6 21.1 4.17 1–17.3 CCS class 1–3 50 31.2 2.2 0.5–9.75 0.970 CCS class 4 40 22.2 2.33 0.56–9.72 Recent myocardial infarction 46.4 27.6 2.27 0.76–6.85 0.864 No recent myocardial infarction 33.3 20 2 0.13–32 LV ejection fraction >50% 38.1 26.3 1.72 0.45–6.64 0.522 LV ejection fraction ≤50% 53.8 26.7 3.21 0.66–15.6 *Including in-hospital death, stroke, prolonged invasive ventilation, myocardial infarction, low cardiac output, acute kidney injury, multiorgan failure, multiple blood transfusion, mediastinal re-exploration, deep sternal wound infection and sepsis. †Unless otherwise stated, the definitions and cut-off values of the preoperative variables were those used for EuroSCORE II. ‡Defined as haemoglobin <13 g/dl for men and <12 g/dl for women. §The creatinine clearance rate, calculated according to the Cockcroft-Gault formula, was used for approximating the GFR. CCS: Canadian Cardiovascular Society; CI: confidence interval; eGFR: estimated glomerular filtration rate; EuroSCORE: European System for Cardiac Operative Risk Evaluation; HYK=histidine-tryptophan-ketoglutarate; LV: left ventricular; MCB: multidose cold blood; OR: odds ratio. Figure 1A – HTK vs. MCB-cohort. PS-matched pairs. Differences on changes of blood levels of haemoglobin, platelets, INR and aPTT between the values early before surgery and the values immediately following patient admission to intensive care unit. aPTT: activated partial thromboplastin time; HTK: histidine-tryptophan-ketoglutarate; INR: international normalized ratio; MCB: multidose cold blood; PS: propensity score. HTK-cohort MCB-cohort Haemoglobin Platelets INR aPTT p=0.538 p=0.642 p=0.281 p=0.981 20 10 –10 –20 –30 –40 0 247