ABC | Volume 115, Nº2, August 2020

Original Article Gatti et al. Custodiol®-HTK solution & prolonged cross-clamp time Arq Bras Cardiol. 2020; 115(2):241-250 Table 3 – In-hospital outcomes*,† Complication Overall series PS-matched pairs HTK cohort n=38 MCB cohort n=110 p-Value HTK cohort n=34 MCB cohort n=34 p-Value In-hospital/30-day death 2 (5.3) 2 (1.8) 0.573 1 (2.9) 0 1.000 Neurological dysfunction (any) 2 (5.3) 8 (7.3) 1.000 2 (5.9) 5 (14.7) 0.427 Transitory‡ 1 (2.6) 8 (7.3) 0.448 1 (2.9) 5 (14.7) 0.197 Permanent (stroke) 1 (2.6) 2 (1.8) 1.000 0 1 (2.9) 1.000 Prolonged (>48 h) invasive ventilation 3 (7.9) 6 (5.5) 0.695 2 (5.9) 3 (8.8) 1.000 Atrial fibrillation, new-onset 6 (15.8) 16 (14.5) 0.862 5 (14.7) 4 (11.8) 1.000 Myocardial infarction 0 1 (0.9) 1.000 0 1 (2.9) 1.000 RV dysfunction 4 (10.5) 8 (7.3) 0.731 4 (11.8) 1 (2.9) 0.356 Low cardiac output 6 (15.8) 10 (9.1) 0.362 3 (8.8) 3 (8.8) 1.000 Prolonged (>12 h) inotropic support 23 (60.5) 57 (51.8) 0.354 19 (55.9) 19 (55.9) 1.000 Intra- and postoperative use of IABP 0 9 (8.2) 0.112 0 3 (8.8) 0.239 Acute kidney injury 8 (21.1) 4 (3.6) 0.002 7 (20.6) 2 (5.9) 0.150 Renal replacement therapy 5 (13.2) 0 0.001 4 (11.8) 0 0.114 Multiorgan failure 3 (7.9) 3 (2.7) 0.339 2 (5.9) 1 (2.9) 1.000 48-h Chest tube output/BSA, ml/m2 685 (390–1074.5) 551 (372.5–970) 0.463 616.5 (390–1074.5) 633 (381–953.5) 0.609 No. of transfused RBC units 1.5 (1–3) 1 (0–2) 0.017 2 (1–3) 1 (0–2) 0.054 Multiple blood transfusion (>2 RBC units) 12 (31.6) 19 (17.3) 0.062 11 (32.4) 7 (20.6) 0.271 Massive blood transfusion (>4 RBC units) 5 (13.2) 2 (1.8) 0.012 4 (11.8) 0 0.114 Mediastinal re-exploration 4 (10.5) 6 (5.5) 0.454 3 (8.8) 2 (5.9) 1.000 Deep sternal wound infection 1 (2.6) 4 (3.6) 1.000 0 1 (2.9) 1.000 Sepsis 0 2 (1.8) 1.000 0 1 (2.9) 1.000 Any major complication§ 17 (44.7) 27 (24.5) 0.019 15 (44.1) 9 (26.5) 0.128 In-hospital stay (days) 13.5 (10–18) 10 (8–15) 0.008 14 (10–19) 10 (8–15) 0.198 Intensive care unit stay (days) 3 (2–5.5) 2 (1.5–3) 0.016 3 (2–5.5) 2 (1.5–3) 0.142 *Continuous variables were expressed as median and the range between the first and the third quartile. Categorical variables were expressed as frequencies and percentages. †Unless otherwise stated, the definitions of the postoperative complications were in accordance with the internationally agreed definitions of complications after cardiac surgery. ‡Including delayed awakening, manifest psychiatric disorder and seizures. §Including in-hospital death, stroke, prolonged invasive ventilation, myocardial infarction, low cardiac output, acute kidney injury, multiorgan failure, multiple blood transfusion, mediastinal re-exploration, deep sternal wound infection and sepsis. BSA: body surface area; HYK: histidine-tryptophan-ketoglutarate; IABP: intra-aortic balloon pump; MCB: multidose cold blood; PS: propensity score; RBC: red blood cells; RV: right ventricular. could depend from a number of aspects related to different surgical teams, adopted surgical techniques, and protocols of perioperative management, as well as from a potential unexplained variability of patients. Author contributions Conception and design of the research and Analysis and interpretation of the data: Gatti G, Taffarello P, Forti G, Gripari C, Gustin G, Castaldi G, Fiorica I, Pappalardo A; Acquisition of data: Gatti G, Taffarello P, Forti G, Gripari C, Gustin G, Castaldi G, Fiorica I; Statistical analysis: Gatti G; Writing of the manuscript: Gatti G, Taffarello P; Critical revision of the manuscript for intellectual content: Gatti G, Taffarello P, Forti G, Gripari C, Gustin G, Pappalardo A. Potential Conflict of Interest No potential conflict of interest relevant to this article was reported. Sources of Funding There were no external funding sources for this study. Study Association This study is not associatedwith any thesis or dissertationwork. Ethics approval and consent to participate This article does not contain any studies with human participants or animals performed by any of the authors. 246