ABC | Volume 114, Nº2, Fevereiro 2020

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Di Salvo TG, Mathier M, SemigranMJ, Dec GW. Preserved right ventricular ejection fraction predicts exercise capacity and survival in advanced heart failure. J Am Coll Cardiol. 1995;25(5):1143-53. 19. Funck-Brentano C, Boelle PY, Verstuyft C, Bornert C, Becquemont L, Poirier JM. Measurement of CYP2D6 and CYP3A4 activity in vivo with dextromethorphan: sources of variability and predictors of adverse effects in 419 healthy subjects. Eur J Clin Pharmacol. 2005;61(11):821-9. 20. Cohn JN, Johnson GR, Shabetai R, Loeb H, Tristani F, Rector T, et al. Ejection fraction, peak exercise oxygen consumption, cardiothoracic ratio, ventricular arrhythmias, and plasma norepinephrine as determinants of prognosis in heart failure. The V-HeFT VA Cooperative Studies Group. Circulation. 1993;87(6 Suppl):VI5-16. 21. Koelling TM, Joseph S, Aaronson KD. Heart failure survival score continues to predict clinical outcomes in patients with heart failure receiving beta- blockers. J Heart Lung Transplant. 2004;23(12):1414-22. 22. LeeWH, Packer M. Prognostic importance of serum sodium concentration and its modification by converting-enzyme inhibition in patients with severe chronic heart failure. Circulation. 1986;73(2):257-67. 23. HulsmannM,BergerR,SturmB,BojicA,WoloszczukW,Bergler-Klein J,etal. Prediction of outcome by neurohumoral activation, the six-minutewalk test and theMinnesota Living withHeart FailureQuestionnaire in an outpatient cohort with congestive heart failure. Eur Heart J. 2002;23(11):886-91. Referências dos dados, Análise estatística e Redação do manuscrito: Gonçalves AV; Revisão crítica do manuscrito quanto ao conteúdo intelectual importante: Pereira-da-Silva T, Soares R, Abreu A, Ferreira RC. Potencial conflito de interesses Declaro não haver conflito de interesses pertinentes. Fontes de financiamento O presente estudo não teve fontes de financiamento externas. Vinculação acadêmica Não há vinculação deste estudo a programas de pós- graduação. Aprovação ética e consentimento informado Este estudo foi aprovado pelo Comitê de Ética do Centro Hospitalar Lisboa Central sob o número de protocolo CA2257. Todos os procedimentos envolvidos nesse estudo estão de acordo com a Declaração de Helsinki de 1975, atualizada em 2013. O consentimento informado foi obtido de todos os participantes incluídos no estudo. 217