ABC | Volume 115, Nº2, August 2020

Original Article Almeida Junior et al. Takotsubo Multicenter Registry (REMUTA) Arq Bras Cardiol. 2020; 115(2):207-216 invasive ventilation, and 7.7% use of mechanical circulatory support. Analyzing predictors of mortality in our registry, we found that secondary TTS was largely responsible for this high mortality. These patients who developed TTS within contexts where another disease was the reason for hospitalization appear to have very different characteristics from those with primary TTS. A recently published review article shows that, in secondary TTS, the men-women ratio is much more balanced than in primary TTS, namely 1:1 to 1:3 in secondary TTS, in comparison with 1:9 in primary TTS. Another important difference is that the presence of chest pain in primary TTS is 75%, while it is under 20% in TTS. This corroborates our finding that chest pain was an independent protective factor against mortality. Furthermore, patients with secondary TTS had higher rates of shock (30% – 69% versus 9.9%) and in-hospital Figure 2 – Medications used during hospital stay. ACEI: angiotensin converting enzyme inhibitors;ARB: angiotensin receptor blockers Figure 1 – Changes in segmental contraction patterns 211