ABC | Volume 115, Nº2, August 2020

Review Article Trombetta et al. BDNF in cardiovascular protection and exercise Arq Bras Cardiol. 2020; 115(2):263-269 1. GBD2015Mortality and causes of death collaborators. Global, regional, and national life expectancy, all-causemortality, and cause-specificmortality for 249 causes of death, 1980-2015: a systematic analysis for theGlobal Burden of Disease Study 2015. Lancet. 2016;388(10053):1459-544. 2. Siqueira ASE, Siqueira-FilhoAG, LandMGP . Analysis of the Economic Impact of Cardiovascular Diseases in the Last Five Years in Brazil. Arq Bras Cardiol. 2017;109(1):39-46. 3. Caporali A, Emanueli C. Cardiovascular actions of neurotrophins. Physiol Rev. 2009;89(1): 279–308. 4. Da Luz PL, Favarato D. A disfunção endotelial como índice prognóstico e alvo terapêutico. In: Da Luz PL, Laurindo FRM, Chagas ACP. Endotélio e doenças cardiovasculares. São Paulo: Ed. Atheneu; 2003. p. 203-20. 5. Rajendran P, Rengarajan T, Thangavel J, Nishigaki Y, Sakthisekaran D, Sethi G, et al. The vascular endothelium and human diseases. Int J Biol Sci. 2013;9(10):1057-69. 6. Hempstead BL. Dissecting the diverse actions of pro- and mature neurotrophins. Curr Alzheimer Res. 2006;3(1):19-24. 7. Ieda M, Kanazawa H, Ieda Y, Kimura K, Matsumura K, Tomita Y, et al. Nerve growth factor is critical for cardiac sensory innervation and rescues neuropathy in diabetic hearts. Circulation. 2006;114(22):2351–63. 8. Usui T, Naruo A, Okada M, Hayabe Y, Yamawaki H. Brain-derived neurotrophic factor promotes angiogenic tube formation through generation of oxidative stress in human vascular endothelial cells. Acta Physiol. 2014;211(2):385-94. 9. Phillips C. Lifestyle modulators of neuroplasticity: how physical activity, mental engagement, and diet promote cognitive health during aging. Neural Plast. 2017;2017:3589271. 10. Cotman CW, Berchtold NC. Exercise: a behavioral intervention to enhance brain health and plasticity. Trends Neurosci. 2002;25(6):295–301. 11. Ferris LT , Williams JS, Shen CL. The effect of acute exercise on serum brain- derived neurotrophic factor levels and cognitive function. Med Sci Sports Exerc. 2007;39(4):728-34. 12. Lemos JR Jr , Alves CR, de Souza SB, Marsiglia JD, Silva MS, Pereira AC, et al. Peripheral vascular reactivity and serumBDNF responses to aerobic training are impaired by the BDNF Val66Met polymorphism. Physiol Genomics. 2016;48(2):116-2 13. Seifert T , Brassard P , WissenbergM, Rasmussen P , Nordby P , Stallknecht B, et al. Endurance training enhances BDNF release from the human brain. Am J Physiol Regul Integr Comp Physiol. 2010;298(2):R372-7. 14. Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, et al. The BDNF Val66Met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell. 2003;112(2):257-69. 15. Shimizu E, Hashimoto K, Iyo M. Ethnic differences of the BDNF 196 G/A (Val66Met) polymorphism frequencies: the possibility to explain ethnic metal traits. Am J Med Genet B Neuropsychiatr. 2004;126B(1):122-3. 16. Pivac N, Kim B, Nedić G, Joo YH, Kozarić-Kovačić D, Hong JP, et al. Ethnic differences in brain-derived neurotrophic factor Val66Met polymorphism in croatian and korean healthy participants. Genomics. 2009;50(1):43-8. 17. Chen ZY, Patel PD, Sant G, Meng CX, Teng KK, Hempstead BL, et al. Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretorycellsandcorticalneurons. JNeurosci.2004;24(18):4401-11. 18. Tang SW, Chu E, Hui T, Helmeste D, Law C. Influence of exercise on serum brain-derivedneurotrophic factorconcentrations inhealthyhumansubjects. Neurosci Lett. 2008;431(1):62-5. 19. Erickson KI, Miller DL, Roecklein KA. The aging hippocampus: interactions betweenexercise,depression,andBDNF. Neuroscientist.2 012;18(1):82-97. 20. Howells DW, Porritt MJ, Wong JY, Batchelor PE, Kalnins R, Hughes AJ, et al. ReducedBDNFmRNAexpression intheParkinson’sdiseasesubstantianigra. Exp Neurol. 2000;166(1):127–35. 21. Michalski B, Fahnestock M. Pro-brain-derived neurotrophic factor is decreased in parietal cortex in Alzheimer’s disease. Brain Res Mol Brain Res. 2003;111(1/2):148–54. 22. ZhaoWQ, Cheng H, QuonMJ, AlkonDL. Insulin and the insulin receptor in experimental models of learning andmemory. Eur J Pharmacol. 2005:490(1- 3):71-81. 23. Li G, Peskind ER, Millard SP, Chi P, Sokal I, Yu CE, et al. Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects. PLoS One. 2009;4(5):e 5424. 24. Ma JC, Duan MJ, Sun LL, Yan ML, Liu T, Wang Q, et al. Cardiac over- expression of microRNA-1 induces impairment of cognition in mice. Neuroscience. 2015;299:66-78. 25. Hashimoto K, Shimizu E, Iyo M. Critical role of brain-derived neurotrophic factor in mood disorders. Brain Res Rev. 2004;45(2):104-14. 26. Zoladz JA, Pilc A. The effect of physical activity on the brain derived neurotrophic factor: from animal to human studies. J Physiol Pharmacol. 2010;61(5):533-41. 27. Ernfors P, Ibanez CF, Ebendal T, Olson L, Persson H. Molecular cloning and neurotrophic activities of a proteinwith structural similarities to nerve growth factor: developmental and topographical expression in the brain. Proc Natl Acad Sci U S A. 1990;87(14):5454-8. 28. MalcangioM,LessmannV.Acommonthreadforpainandmemorysynapses? Brain-derived neurotrophic factor and trkB receptors. Trends Pharmacol Sci. 2003;24(3):116-21. 29. DonovanMJ, Miranda RC, Kraemer R, McCaffrey TA, Tessarollo L, Mahadeo D, et al. Neurotrophin and neurotrophin receptors in vascular smooth muscle cells. Regulation of expression in response to injury. Am J Pathol. 1995;147(2):309–24. 30. Lommatzsch M, Zingler D, Schuhbaeck K, Schloetcke K, Zingler C, Schuff- Werner P, et al. The impact of age, weight and gender on BDNF levels in human platelets and plasma. Neurobiol Aging. 2005;26(1):115-23. 31. Pan W , Banks WA, Fasold MB, Bluth J, Kastin AJ. Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology. 1998;37(12):1553-61. 32. FujimuraH,AltarCA,ChenR,NakamuraT,NakahashiT,Kambayashi JI,etal. Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation. Thromb Haemost. 2002;87(4):728-34. References Potential Conflict of Interest No potential conflict of interest relevant to this article was reported. Sources of Funding There were no external funding sources for this study. Study Association This study is not associated with any thesis or dissertation work. 267