ABC | Volume 114, Nº4, April 2020

Original Article Souza et al. NT-proBNP in acute coronary syndromes Arq Bras Cardiol. 2020; 114(4):666-672 Figure 2 – Comparison of the ROC curves between original GRACE (0.82; 95% CI = 0.68-0.97) and GRACE-BNP logistic (0.83; 95% CI = 0.69-0.97) and categorical (0.82; 95% CI = 0.68-0.96) shows similar C-statistics among the three scores. Categorical GRACE-BNP (0.82) Logistic GRACE-BNP (0.83) Original GRACE (0.82) Reference Line 1.0 1.0 0.8 0.8 0.6 0.6 0.4 0.4 0.2 0.2 0.0 0.0 Sensitivity 1 – Specificity Table 3 – Analysis of net reclassification by the GRACE-BNP numerical score in relation to the GRACE score in the definition of high risk N Reclassification to high risk Reclassification to low risk NRI p Value Outcome 17 3 0 +0.18% Without outcome 335 9 0 -0.02% Total 352 12 0 -0.15% 0.14 Conclusion Despite its association with risk in a univariate approach, it has not been proven that the use of NT-proBNP as a measure of left ventricular dysfunction increases the in-hospital prognostic value of GRACE score in ACS. Author contributions Conception and design of the research: Souza TMB, Cerqueira Jr. AMS, Correia L; Acquisition of data: Souza TMB, Cerqueira Jr. AMS, Suerdieck JG, Sá NC, Sodré GS, Correia VCA, Lacerda YF, Fonseca LL, Noya-Rabelo MM; Analysis and interpretation of the data: Souza TMB, Cerqueira Jr. AMS, Suerdieck JG, Sá NC, Sodré GS; Statistical analysis: Souza TMB, Cerqueira Jr. AMS, Suerdieck JG, Sá NC, Correia VCA, Lacerda YF, Fonseca LL, Noya-Rabelo MM, Correia L; Critical revision of the manuscript for intellectual content: Souza TMB, Cerqueira Jr. AMS, Suerdieck JG, Sá NC, Sodré GS, Correia VCA, Lacerda YF, Fonseca LL, Noya‑Rabelo MM, Correia L. Potential Conflict of Interest No potential conflict of interest relevant to this article was reported. Sources of Funding There were no external funding sources for this study. Study Association This study is not associatedwith any thesis or dissertationwork. 670