ABC | Volume 113, Nº5, November 2019

Original Article Saraiva et al. Normal values for new echocardiographic techniques Arq Bras Cardiol. 2019; 113(5):935-945 Figure 1 – Flowchart of enrollment of subjects in the present study. Total adult participants with negative CD serology screened for the study: 296 Total included: 77 RT3DE LA volume 75 RT3DE LV volume 64 LA strain 76 RV strain 67 LV strain LV-GLS: 74 LV-GCS: 75 LV-GRS: 75 LV-twist: 70 Total participants with good image quality for each of the analyzed parameters Exclusion: Hypertemsion: 116; Dilated cardiomyopathy: 19; Valvular heart disease: 6; Ischemic heart disease: 9; ECG abnormalities: 18; Cardiovascular symptoms: 9; Congenital heart disease: 2; Hypertrophic cardiomyopathy: 1; Infectious diseases: 6; Diabetes: 4; Hypothyroidism: 4; Digestive symptoms: 15; Psychiatric disease: 2; Obesity: 8. Men presented larger LA and LV diameters and a tendency for larger LVmass while E/E’ ratio was higher in women (Table 1). 3D echocardiography analysis of LA volume, function and strain Except for two, good image quality was obtainable for 3DE LA volume analysis from all participants. Except for one, LA strain analysis was feasible in all participants. LA volume and function values obtained by 3DE and STE are presented in Table 2. Pre-A LA volume was slightly larger and passive LA emptying fraction was smaller in men than in women. There were no differences regarding LA ε parameters between men and women (Table 2). 3D echocardiography analysis of LV volume, function and strain Images of enough quality to analyze 3D LV volumes were obtained in 64 (83%) participants. Three patients were excluded from LV-GLS analysis and two patients were excluded from LV-GCS and LV-GRS analyses due to poor imaging quality. Seven patients were excluded from LV twist and torsion analyses due to poor imaging quality for LVrot analysis in either basal or apical short-axis views. Values for LV volume and function obtained by 3DE and STE are presented in Table 3. LV end-diastolic volume was larger and end-systolic volume presented a tendency to be larger in men than women while 3D LV ejection fraction did not differ between them. LV-GCS was slightly higher in women than in men, while LV-GLS, LV-GRS, LV rotation and torsion did not differ between them (Table 3). RV strain analysis Good imaging quality for RV ε analysis was obtainable from 67 (87%) participants. RV function values obtained by STE are presented in Table 4. RV ε parameters did not differ between men and women (Table 4). Correlation between age and new echocardiographic indexes Regarding LA volume and function, age presented fair positive correlation with minimum LA (r = 0.27, p = 0.02) and pre-A volume (r = 0.33, p = 0.004), and fair negative correlation with total LA emptying fraction (r = -0.26, p = 0.02) and passive LA emptying fraction (r = -0.35, p=0.001, Fig. 2A). Age presented a moderate negative correlation with LAScd (r = -0.42, P=0.0001, Fig. 2B) and a fair negative correlation with LASr (r = -0.39, p = 0.0004). Age did not correlate with maximum LA volume, active LA emptying fraction and LASct. Regarding LV volume and function, age presented fair negative correlation with LV end-diastolic (r = -0.31, 937