ABC | Volume 113, Nº5, November 2019

Original Article Vasconcelos et al. Antiarrhythmic effects of d-limonene Arq Bras Cardiol. 2019; 113(5):925-932 1. Magoon R, Choudhury A, Malik V, Sharma R, Kapoor PM. Pharmacological update: New drugs in cardiac practice: A critical appraisal. Ann Card Anaesth. 2017;20(Sup):S49-S56. 2. DanGA, Martinez-Rubio A, Agewall S, Boriani G, BorggrefeM, Gaita F, et al. Antiarrhythmic drugs-clinical use and clinical decisionmaking: a consensus document from the European Heart Rhythm Association (EHRA) and European Society of Cardiology (ESC) Working Group on Cardiovascular Pharmacology, endorsed by the Heart Rhythm Society (HRS), Asia-Pacific Heart RhythmSociety (APHRS) and International Society of Cardiovascular Pharmacotherapy (ISCP). Europace. 2018;20(5):731-2. 3. De Cerqueira SVS, GondimANS, Roman-Campos D, Cruz JS, Passos AGD, Lauton-Santos S, et al. R(+)-pulegone impairs Ca2+homeostasis andcauses negative inotropism in mammalian myocardium. Eur. J. Pharmacol. 2011;672(1-3):135–42. 4. Santos-Miranda A, Gondim AN, Menezes-Filho JE, Vasconcelos CM, Cruz JS, Roman-Campos D. Pharmacological evaluation of R(+)-pulegone on cardiac excitability: role of potassiumcurrent blockage and control of action potential waveform. Phytomedicine. 2014;21(10):1146-53. 5. Menezes-Filho JE, Gondim AN, Cruz JS, de Souza AA, Santos JN, Conde- Garcia EA, et al. Geraniol blocks calcium and potassium channels in the mammalian myocardium: useful effects to treat arrhythmias. Basic Clin Pharmacol Toxicol. 2014;115(6):534-44. 6. Vasconcelos CML, Oliveira ISN, Santos JNA, Souza AA, Menezes-Filho JER, SilvaNeto JA, et al. Negative inotropismof terpenes on guinea pig left atrium: structure-activity relationships. Nat Prod Res. 2018;32(12):1428-31. 7. Dos Passos Menezes P, Dos Santos PB, Dória GA, de Sousa BM, Serafini MR, Nunes PS, et al. Molecular Modeling and Physicochemical Properties of Supramolecular Complexes of Limonene with α - and β -Cyclodextrins. AAPS PharmSciTech. 2017;18(1):49–57. 8. Sun J. D-Limonene: safety and clinical applications. Altern Med Rev. 2007;12(3):259-64. 9. RobertoD, Micucci P, Sebastian T, Graciela F, Anesini C. Antioxidant activity of limonene on normal murine lymphocytes: relation to H 2 O 2 modulation and cell proliferation. Basic Clin Pharmacol Toxicol. 2010;106(1) 38–44. 10. Andrade TU, Brasil GA, Endringer DC, da Nóbrega FR, De Sousa DP. Cardiovascular Activity of the Chemical Constituents of Essential Oils. Molecules. 2017;22(9):1539. 11. DeSousaDP,MesquitaRF,deAraújoRibeiroLA,deLimaJT.SpasmolyticActivityof CarvoneandLimoneneEnantiomers.NatProdCommun.2015;10(11):1893-6. 12. Santiago JVA, Jayachitra J, ShenbagamM, Nalini N. d-limonene attenuates blood pressure and improves the lipid and antioxidant status in high fat diet and L-NAME treated rats. J Pharm Sci Res. 2010;2(11):752-8. 13. GondimANS, Lara A, Santos-Miranda A, Roman-Campos D, Lauton-Santos S, Menezes-Filho JER, et al. (-)-Terpinen-4-ol changes intracellular Ca 2+ handling and induces pacing disturbance in rat hearts. Eur J Pharmacol. 2017 Jul 15;807:56-63. 14. SantosMS, Oliveira ED, Santos-Miranda A, Cruz JS, GondimANS, Menezes- Filho JER, et al. Dissection of the effects of quercetin onmousemyocardium. Basic & Clinical Pharmacol Toxicol. 2017;120(6):550–9. 15. Zhou P, Zhang SM,WangQL,WuQ, ChenM, Pei JM. Anti-Arrhythmic Effect of Verapamil Is Accompanied by Preservation of Cx43 Protein in Rat Heart, PLoS ONE. 2013;8(8):e71567. 16. Curtis MJ, Walker MJ. Quantification of arrhythmias using scoring systems: an examination of seven scores in an in vivo model of regional myocardial ischaemia, Cardiovasc Res. 1988;22(9):656–65. 17. Lahlou S, Figueiredo AF, Magalhães PJ, Leal-Cardoso JH. Cardiovascular effects of 1,8-cineole, a terpenoid oxide present inmany plant essential oils, in normotensive rats. Can J Physiol Pharmacol. 2002;80:(12)1125–31. 18. Lahlou S, Interaminense LF, Leal-Cardoso JH, Duarte GP. Antihypertensive effects of the essential oil of Alpinia zerumbet and its main constituent, terpinen-4-ol, in DOCA-salt hypertensive conscious rats. Fundam Clin Pharmacol. 2003;17(3):323–30. 19. Menezes IA, Barreto CM, Antoniolli AR, Santos MR, de Sousa DP. Hypotensive activity of terpenes found in essential oils. Z Naturforsch C. 2010;65(9-10):562-6. 20. Nademanee K, Singh BN. Control of cardiac arrhythmias by calcium antagonism. Ann N Y Acad Sci. 1988;522:536–52. 21. Wann LS, Curtis AB, Ellenbogen KA, Estes NA, Ezekowitz MD, Jackman VM, et al., American College of Cardiology F, American Heart A, European Society of C, Heart Rhythm Management of patients with atrial fibrillation (compilation of 2006 ACCF/AHA/ESC and 2011 ACCF/AHA/HRS recommendations): a report of the American College of Cardiology/ American Heart Association Task Force on practice guidelines. Circulation 2013;127(18):1916–26. 22. Prystowsky EN. Effects of bepridil on cardiac electrophysiologic properties. Am J Cardiol. 1992;69(11):63D-67D. 23. McGuill MW, Rowan AN. Biological effects of blood loss: implications for sampling volumes and techniques. ILAR J. 1989;31(4):5–18. 24. Bers DM. Cardiac excitation–contraction coupling . Nature 2002;415(6868):198–205. 25. De Sousa DP, Junior GA, Andrade LN, Calasans FR, Nunes XP, Barbosa-Filho JM. Structure and spasmolytic activity relationships of monoterpene analogues found in many aromatic plants. Z Naturforsch C. 2008; 63(11-12):808-12. References 931