ABC | Volume 113, Nº5, November 2019

Original Article Vasconcelos et al. Antiarrhythmic effects of d-limonene Arq Bras Cardiol. 2019; 113(5):925-932 Figure 5 – In vivo effects of DL (10 mg/kg) on arrhythmias induced by S(−)-Bay K 8644 in anesthetized rats. Original traces A) and bar chart graphic of arrythmia score B) and heart rate C) before and after DL treatment. Data are mean ± SD and were analysed by unpaired Student T-test (B) (* p < 0,05 vs control, n = 4) and ANOVA followed by Bonferroni post-test (C) (* p < 0,05 vs control, # p < 0.05 vs Bay K8644, n = 4). VPB: ventricular premature beats, VT: ventricular tachycardia; VF: ventricular fibrillation. Vehicle Vehicle Bay K8644 Arrhythmia Bay K8644 + DL Bay K8644 + DL Bay K8644 Score arrhythmia (a.u.) Heart rate (bpm) Bay K8644 + DL Bay K8644 372 ms 235 ms 446 ms VPB VT VF 5 mV 5 mV * * * # 25 20 15 10 5 0 400 350 250 300 200 100 50 150 0 A B C Author contributions Conception and design of the research: Vasconcelos CML, Souza DS, Lima BS, Araujo AAS, Quintans-Junior LJ, Almeida JRGS, Oliveira AP, Santana-Filho VJ, Barreto AS, Santos MRV; Acquisition of data: Vasconcelos CML, Nascimento G, Souza DS, Lima BS, Durço A; Analysis and interpretation of the data: Vasconcelos CML, Nascimento G, Souza DS, Lima BS, Araujo AAS, Durço A, Oliveira AP, Santana-Filho VJ, Barreto AS, Santos MRV; Statistical analysis: Vasconcelos CML, Nascimento G, Souza DS, Araujo AAS, Santos MRV; Obtaining financing: Vasconcelos CML, Araujo AAS, Quintans-Junior LJ, Almeida JRGS, Santana-Filho VJ, Santos MRV; Writing of the manuscript: Vasconcelos CML, Nascimento G, Souza DS, Durço A, Quintans-Junior LJ, Barreto A, Santos MRV; Critical revision of the manuscript for intellectual content: Vasconcelos CML, Araujo AAS, Quintans-Junior LJ, Almeida JRGS, Oliveira AP, Santana-Filho VJ, Barreto AS, Santos MRV. Potential Conflict of Interest No potential conflict of interest relevant to this article was reported. Sources of Funding This study was funded by CNPq, CAPES and FAPITEC/SE. Study Association This study is not associatedwith any thesis or dissertationwork. Ethics approval and consent to participate This study was approved by the Ethics Committee on Animal Experiments of the Universidade Federal de Sergipe under the protocol number 13/2016. 930