IJCS | Volume 32, Nº1, January/ February 2019

DOI: 10.5935/2359-4802.20180081 55 ORIGINAL ARTICLE International Journal of Cardiovascular Sciences. 2019;32(1)55-60 Mailing Address: Silene Jacinto da Silva Av. João Rita Dias, Q 105 Lt 06. Postal Code: 74.455-360, Jardim Leblon, Goiânia, GO - Brazil. E-mail: silenejacintoa@gmail.com Influence of ACE Polymorphism on Echocardiographic Data of Patients with Heart Failure Silene Jacinto da Silva, 1 S alvador Rassi, 1 Alexandre da Costa Pereira 2 Universidade Federal de Goiás (UFG), 1 Goiânia, GO - Brazil Faculdade de Medicina da Universidade de São Paulo (FMUSP), 2 São Paulo, SP - Brazil Manuscript received January 24, 2018; revised manuscript May 06, 2018; accepted June 26, 2018. Abstract Background: Angiotensin converting enzyme (ACE) polymorphism has been associated with different clinical and echocardiographic parameters in patients with heart failure (HF). However, no studies have been investigated such association with HF caused by Chagas disease. Objectives: To perform a genetic study to evaluate the frequency of ACE polymorphism in patients with HF caused by Chagas disease attending a university hospital in the central-west region and its association with echocardiographic findings. Methods: Descriptive study of ACE polymorphism (I/D) and echocardiographic data of 103 patients with HF caused by Chagas disease. Echocardiographic parameters were compared between the genotypes using the ANOVA test. Results: Genotypic distribution of the ACE polymorphism was 16.5% DD, 57.3% DI and 26.2% II. There was no statistically significant difference in the distribution of genotypes between men and women. The echocardiographic findings were: left ventricular ejection fraction: 43.8 ± 14.8 (DD) vs. 42.3 ± 11.6 (ID) vs. 44.9 ± 13.0 (II), p = 0.664; left ventricular diastolic diameter: 59.2 ± 9.7 (DD) vs. 60.3 ± 7.6 (ID) vs. 59.7 ± 78.1 (II), p = 0.879; left ventricular systolic diameter: 48.6 ± 12.8 (DD) vs. 50.6 ± 9.7 (ID) vs. 49.3 ± 11.9 (II), p = 0.753; and left atrial volume: 44.9 ± 10.1 (DD) vs. 40.9 ± 9.6 (ID) vs. 38.2 ± 7.8 (II), p = 0.068. Significant correlation coefficients were found for gender, age, ethnicity, heart rate and dyslipidemia. Conclusion: ACE polymorphism was not associated with echocardiographic findings in patients with HF caused by Chagas disease. (Int J Cardiovasc Sci. 2019;32(1)55-60) Keywords: Heart Failure; Angiotensins; Polymorphism, Genetic; Chagas Disease; Echocardiography/methods. Introduction Chagas disease, described more than 100 years ago by Carlos Chagas, is considered one of the most neglected diseases in the world by the World Health Organization (WHO). 1 It is an important cause of heart failure (HF) in lowsocioeconomic regions, leading to highmorbidity and mortality. 2 In the central-west region of Brazil, Chagas disease has been considered the main cause of HF. 3-5 Most health problems, including HF, have a multifactorial etiology, that involves environmental, lifestyle, and genetic factors. 6 Multifactorial disorders are characterized by genotypic contributions from many genes that interact with each other and with environmental factors. 6 Genetic composition, associated with environmental factors, can predispose an individual todiseases and response topharmacological interventions. 7 Doppler echocardiography is a useful method for diagnostic confirmation, evaluation of etiology, pathophysiological and hemodynamic model, prognosis and indication of therapeutic alternatives for patients with HF. 8 Due to the importance and magnitude of this condition, clinical therapy of HF patients require a multidisciplinaryapproach, andsearch for newtechniques.