IJCS | Volume 31, Nº6, November / December 2018

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The mechanisms of alloxan-and streptozotocin-induced diabetes. Diabetologia. 2008;51(2):216-26. 13. Cesaretti ML, Ginoza M, Ribeiro AB, Kohlmann O Jr. [Systemic hemodynamic and left ventricular function of diabetic-induced hypertensive rats]. Arq Bras Endocrinol Metabol. 2010;54(9):842-51. 14. Lee Y, Kim JH, Hong Y, Lee SR, Chang KT, Hong Y. Prophylactic effects of swimming exercise on autophagy-inducedmuscle atrophy in diabetic rats. Lab Anim Res. 2012;28(3):171-9. 15. Manchado FD, Gobatto CA, Contarteze RV, Papoti M, Mello MA. The maximal lactate steady state is ergometer-dependent in experimental model using rats. Rev Bras Med Esporte. 2006;12(5):233e-6e. 16. BrumPC, Forjaz CL, Tinucci T, Negrão CE. Adaptações agudas e crônicas do exercício físico no sistema cardiovascular. Rev paul Educ Fís (São Paulo). 2004;18:21-31. 17. Balmain JH, Biggers J, Claringbold P. Micromethod for the estimation of glycogen in the genital organs of the, mouse. Austr J Biol Sciences.1956;9(1):139-46. 18. 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Cetoacidose diabética. Revista Médica de Minas Gerais. 2008;18(3 supl 4):S6-S10. 23. Sociedade Brasileira de Diabetes. Diretrizes da Sociedade Brasileira de Diabetes. 2013-2014. São Paulo: AC Farmacêutica; 2014. 24. Tanaka LY. Efeito do exercício físico aeróbio no relaxamento aórtico de ratos e no controle da biodisponibilidade do óxido nítrico. [Dissertação]. São Paulo: Faculdade de Medicina da Universidade de São Paulo; 2008. 25. Galassetti P, Riddell MC. Exercise and Type 1 Diabetes (T1DM). Compr Physiol. 2013;3(3):1309-36. 26. Krause MP, Riddell MC, Hawke TJ. Effects of type 1 diabetes mellitus on skeletal muscle: clinical observations and physiological mechanisms. Pediatr Diabetes. 2011;12(4 Pt 1):345-64. 27. Stilli D, Lagrasta C, Berni R, Bocchi L, Savi M, Delucchi F, et al. Preservation of ventricular performance at early stages of diabetic cardiomyopathy involves changes in myocyte size, number and intercellular coupling. Basic Res Cardiol. 2007;102(6):488-99. 28. Silva E, Natali AJ, Silva MF, Gomes GJ, Cunha DN, Ramos RM, et al. Ventricular remodeling in growing rats with experimental diabetes: The impact of swimming training. Pathol Res Pract. 2013;209(10):618-26. 29. Castellar A, Remedio R, Barbosa R, Gomes R, Caetano FH. Collagen and reticular fibers in left ventricular muscle in diabetic rats: Physical exercise prevents its changes? Tissue Cell. 2011;43(1):24-8. References Moura et al. Diabetic rats and aerobic training Int J Cardiovasc Sci. 2018;31(6)610-618 Original Article Statistical analysis: GomesMFP.Writing of themanuscript: Medeiros A. Critical revision of the manuscript for intellectual content: Estadella D, Medeiros A. Potential Conflict of Interest No potential conflict of interest relevant to this article was reported. Sources of Funding There were no external funding sources for this study. Study Association This study is not associated with any thesis or dissertation work. Ethics approval and consent to participate This study was approved by the Ethics Committee on Animal Experiments of the Universidade Federal de São Paulo - UNIFESP under the protocol number 0384/12.

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