IJCS | Volume 31, Nº6, November / December 2018

613 Table 1 - Glycemia, body weight and exercise tolerance before (pre) and after (post) 8 weeks of either sedentary status or exercise training Parameter Glycemia (mg/dL) Body weight (g) Exercise tolerance (min) Groups Pre CTR 70 ± 6 237 ± 15 29 ± 2 DMC 229 ± 24 a 219 ± 8 19 ± 1 a DMS 282 ± 27 a 234 ± 8 21 ± 1 a DMT 250 ± 25 a 193 ± 7 20 ± 1 a Post CTR 65 ± 8 381 ± 19 * 23 ± 2 * DMC 284 ± 18 a 196 ± 12 a 16 ± 1 a DMS 252 ± 12 a 227 ± 8 a 23 ± 2 b DMT 346 ± 27 abc* 211 ± 10 a 28 ± 2 b * CTR (n = 10), DMC (n = 11), DMS (n = 12), and DMT (n = 9). a ≠ CTR, b ≠ DMC, c ≠ DMS. * ≠ pre (p < 0.05). Results are presented as mean ± standard derivation of the mean; Two-way ANOVA with post-hoc Bonferroni test. Moura et al. Diabetic rats and aerobic training Int J Cardiovasc Sci. 2018;31(6)610-618 Original Article group showed higher glycemia at the end of the protocol when compared to all other groups (Table 1). In relation to body weight, diabetic groups (DMC, DMS and DMT) showed lower body weight when compared to the CTR at the end of the protocol. Only the CTR group showed a significant (p < 0.05) increase in body weight at the end when compared to the beginning of the protocol (Table 1). Diabetic groups (DMC, DMS and DMT) displayed statistically significant (p < 0.05) lower exercise tolerance at the beginning of the protocol when compared to the CTR group. Only the DMT group showed a significant (p < 0.05) increase in exercise tolerance at the end when compared to the beginning of the protocol. Although the DMS group did not show a significant increase at the end compared to the beginning of the protocol, exercise tolerance was significantly higher (p < 0.05) than in the DMC group (Table 1) at the end of the protocol. The CTR group showed a decrease in exercise tolerance at the end compared to the beginning of the protocol. The data related to the analysis performed in the soleus and EDL muscles are shown in table 2. The DMC group showed similar cross-sectional areas of soleus and EDL muscle fibers when compared to the CTR group. Only exercise training on the treadmill was able to increase this variable, since the DMT group showed greater areas in the fibers of both muscles when compared to the CTR, DMC and DMS groups (p < 0.05). Regarding glycogen levels, the DMC showed similar levels in soleus but decreased levels in the EDL (p < 0.05) when compared to the CTR group. Both ET protocols were able to increase the glycogen levels in both muscles (p < 0.05). In addition, the DMS group showed a higher level in relation to the CTR group. When comparing the wet weight of the soleus and EDL muscles, the DMC showed lower weights of both muscles corrected for tibial length when compared to the CTR group. The ET protocols used in this study had no effect on this variable, since no differences were found between the DMC, DMS and DMT groups. When correcting the weight of the muscles by body weight, there were no significant differences either and, for that reason, these data are not shown. The data for the analysis carried out in the left ventricle are depicted in Table 3. The DMC group showed a cardiac cross-sectional diameter similar to that of the CTR group. However, the exercise-trained groups (DMS and DMT) showed higher (p < 0.05) cardiac cross-sectional diameter when compared to the sedentary groups (CTR andDMC). Moreover, the cardiac cross-sectional diameter of the DMS group was significantly (p < 0.05) higher than that of the DMT group. Left ventricular fibrosis assessed by collagen quantification was not different between the groups. Regarding the wet weight of the left ventricle, the DMC group showed a significant (p < 0.05) decrease when compared to the CTR group and the different