IJCS | Volume 33, Nº4, July and August 2020

DOI: https://doi.org/10.36660/ijcs.20180064 Introduction Among the most common non-communicable chronic diseases worldwide, diabetes mellitus (DM) stands out because it affects more than 340 million people in the world. 1 According to Irigoyen et al., 2 DM has reached epidemic proportions due to factors such as increased life expectancy, high prevalence of obesity and sedentary lifestyle. 2 The main risk factors for the pathogenesis of DM are related to family history and lifestyle, such as impaired fasting blood glucose, reduced glucose tolerance, gestational diabetes, birth weight greater than 4 kg, sedentary lifestyle, dyslipidemia (triglycerides 360 ORIGINAL ARTICLE International Journal of Cardiovascular Sciences. 2020; 33(4):360-367 Mailing Address: Cristiano Teixeira Mostarda Av. dos Portugueses, 1966. Postal Code: 65085-580, Cidade Universitária Dom Delgado, São Luís, MA - Brazil. E-mail: cristiano.mostarda@gmail.com Influence of Family History of Diabetes on Cardiac Autonomic Dysfunction of Adolescents Carlos Alberto Alves Dias-Filho, 1 N ivaldo de Jesus Soares Jr., 1 C arlos José Dias, 1 A ndressa Coelho Ferreira, 1 Carlan da Silva Sena, 1 Janaína de Oliveira Brito-Monzani, 1 Rafael Martins Andrade, 1 A deilson Serra Mendes Vieira ,¹ Leandro Moraes Pinto, 1 W ellington Roberto G. de Carvalho, 2 Cristiano Teixeira Mostarda 1 Universidade Federal do Maranhão, 1 São Luís, MA - Brazil Universidade Federal de Uberlândia, 2 Uberlândia, MG – Brazil Manuscript received October 10, 2018; revised manuscript August 05, 2019; accepted November 03, 2019. Abstract Background: To evaluate cardiac autonomic modulation of adolescents with a family history of diabetic parents. Objective: This study aims to evaluate the influence of a family history of diabetes on cardiac autonomicmodulation. Methods: This is an analytical and cross-sectional study on adolescents between 11 and 18 years of age, of both genders, who were divided into group with a family history of diabetes and a control group without a family history of diabetes. The study protocol consisted of the analysis of heart rate variability, blood pressure, anthropometric measurements, and body composition. Also, by using questionnaires, level of physical activity, sexual maturation, and sleep quality were evaluated. Normality of data distribution was tested using the Kolmogorov-Smirnov test. Then, statistical significance was evaluated using the Student's t-test, and the Hedges’g teste was used for calculation of the effect size. The level of significance adopted in the statistical analysis was 5%. Results: When the group of individuals with a family history of diabetes was compared with the control group, statistically significant differences were observed in the variables the standard deviation of the NN time series interval (SDNN) (43.9 ± 2.2 vs. 53.5 ± 2.6 ms), the square root of the quadratic differences (RMSSD) (41.9 ± 3.3 vs. 52.4 ± 3.2 ms), standard deviation of beat-to-beat instantaneous variability (SD1) (29.7 ± 2.3 vs. 37.1 ± 2.3 ms), long- term standard deviation of continuous RR intervals (SD2) (. 54.1 ± 2.6 vs. 66.66 ± 3.5 ms), and in low frequency (LF) (496.0 ± 49.5 vs. 728 ± 71.6 ms 2 ) and high frequency (HF) (1050.0 ± 120.4 vs. 737.4 ± 98.5 ms 2 ) in the frequency domain. Conclusions: Global autonomic modulation is decreased in adolescents with a family history of diabetes. We also observed a decrease in vagal activity in this group. So, sympathetic autonomic modulation is predominant in this population. (Int J Cardiovasc Sci. 2020; 33(4):360-367) Keywords: Diabetes/heredity; Diabetes/Epidemiology; Adolescent; Body Weight; Body Mass Index, cardiac Autonomic System.