IJCS | Volume 33, Nº4, July and August 2020

354 Figure 1 - Aortic pulse wave velocity increase with age. Figure 2 - Aortic pulse wave velocity and handgrip strength. Pereira & Costa Arterial stiffness in the older adult Int J Cardiovasc Sci. 2020; 33(4):349-356 Original Article pulsatility and increased PP. 24 These hemodynamic adaptations serve the basis for ISH, which is the most prevailing HT phenotype in the very old. 5 Conversely, HT has been proved to cause arterial damage that may accelerate AS. 2,14,23,24 This was also supported by the strong association of BP and vascular resistance withAS demonstrated in the present study. In addition to the expected association of AS with hemodynamic parameters, a significant association of AS was found with kidney function and overall health parameters. In fact, there was an association of AS with creatinine values, with participants with abnormal AS showing higher mean creatinine levels and worse kidney function, which is in line with previous evidence