IJCS | Volume 33, Nº4, July and August 2020

327 1. McEwen BS. Protection and damage from acute and chronic stress: allostasis and allostatic overload and relevance to the pathophysiology of psychiatric disorders. Ann N Y Acad Sci. 2004 Dec;1032:1-7. 2. PetersA, McEwen BS. Stress habituation, body shape and cardiovascular mortality. Neurosci Biobehav Rev. 2015 Sep;56:139-150. 3. Hamer M, Endrighi R, Venuraju SM, Lahiri A, Steptoe A. Cortisol responses to mental stress and the progression of coronary artery calcification in healthy men and women. PLoS One 2012;7(2):e31356. 4. World Health Organization. A global brief on hypertension: silent killer, global public health crisis. Geneva: WHO; 2013. 5. Feihl F, Liaudet L, Levy BI, Waeber B. Hypertension and microvascular remodelling. Cardiovasc Res. 2008;78(2):274-85. 6. Pereira MC, Ribeiro L. Stress, catecholamines and cardiovascular risk. Arq Med. 2012;26(6):245-53. 7. Vaněčková I, Maletínská L, Behuliak M, Nagelová V, Zicha J, Kuneš J. Obesity-related hypertension: possible pathophysiological mechanisms. J Endocrinol. 2014;223(3):R63-R78. 8. Badyal D, Lata H, Dadhich AP. Animal models of hypertension and effect of drugs. Indian J Pharmacol. 2003;35:349-62. 9. Dornas WC, Silva ME. Animal models for the study of arterial hypertension. J Biosci. 2011;36(4):731-7. 10. Conceicao-Vertamatti AG, Borghi F, Canova F, Grassi-Kassisse DM. History of vascular reactivity models and their involvement in hypertension pathogenesis. Vasa. 2017;46(6):431-9. 11. Cuspidi C, Rescaldani M, Sala C, Negri F, Grassi G, Mancia G. Prevalence of electrocardiographic left ventricular hypertrophy in human hypertension: an updated review. J Hypertens. 2012;30(11):2066-73. 12. Mozos I, Caraba A. Electrocardiographic predictors of cardiovascular mortality. Dis Markers. 2015;2015:727401. 13. Mansur PH, Cury LK, Destro-Filho JB, Resende ES, Destro JP, de Oliveira LM, et al. Analysis of electrocardiographic recordings associated with acute myocardial infarction. Arq Bras Cardiol. 2006;87(2):106-14. 14. Rogers K. The Cardiovascular System. Britannica Educational Pub, 2011. 15. Magnani JW, Gorodeski EZ, Johnson VM, Sullivan LM, Hamburg NM, Benjamin EJ, et al. P wave duration is associated with cardiovascular and all-cause mortality outcomes: the National Health and Nutrition Examination Survey. Heart Rhythm. 2011;8(1):93-100. 16. Liew R. Electrocardiogram based predictors of sudden cardiac death in patients with coronary artery disease. Clin Cardiol. 2011;34(8):466-73. 17. Strauss DG, Selvester RH, Lima JA,ArhedenH, Miller JM, GerstenblithG, et al. ECG quantification of myocardial scar in cardiomyopathy patients with or without conduction defects correlation with cardiac magnetic resonance and arrhythmogenesis. Circ Arrhythm Electrophysiol. 2008;1(5):327-36. 18. Haarmark C, Graff C, Andersen MP, Hardahl T, Struijk JJ, Toft E, et al. Reference values of electrocardiogram repolarization variables in a healthy population. J Electrocardiol. 2010;43(1):31-9. 19. Paulis L, Unger T. Novel therapeutic targets for hypertension. Nat Rev Cardiol. 2010;7(8):431-41. 20. Conceicao-Vertamatti AG, Ramos LA, Calandreli I, Chiba AN, Franco DW, Tfouni E, et al. Vascular response of ruthenium tetraamines in aortic ring from normotensive rats. Arq Bras Cardiol. 2015;104(3):185-94. 21. Feketa VV, Balasubramanian A, Flores CM, Player MR, Marrelli SP. Shivering and tachycardic responses to external cooling in mice are substantially suppressed by TRPV1 activation but not by TRPM8 inhibition.Am J Physiol Regul Integr Comp Physiol. 2013;305(9):R1040-50. 22. Ribeiro MO, Antunes E, de Nucci G, Lovisolo SM, Zatz R. Chronic inhibition of nitric oxide synthesis.A newmodel of arterial hypertension. Hypertension. 1992;20(3):298-303. 23. AnishchenkoAM,AlievOI, SidekhmenovaAV, ShamanaevAY, Plotnikov MB. Dynamics of blood pressure elevation and endothelial dysfunction in SHR rats during the development of arterial hypertension. Bull Exp Biol Med. 2015:159(5):591-3. 24. Oikawa M, Wu M, Lim S, Knight WE, Miller CL, Cai Y, et al. Cyclic nucleotide phosphodiesterase 3A1 protects the heart against ischemia- reperfusion injury. J Mol Cell Cardiol. 2013 Nov;64:11-9. 25. Lakics V, Karran EH, Boess FG. Quantitative comparison of phosphodiesterase mRNA distribution in human brain and peripheral tissues. Neuropharmacology. 2010;59(6):367-74. 26. Beca S, Ahmad F, Shen W, Liu J, Makary S, Polidovitch N, et al. PDE3A regulates basal myocardial contractility through interacting with SERCA2a-signaling complexes in mouse heart. Circ Res. 2013;112(2):289-97. 27. Yan C. Cyclic nucleotide phosphodiesterase 1 and vascular aging. Clin Sci. 2015;129(12):1077-81. 28. DiFrancesco D. Cardiac pacemaker (If) current: physiological and pharmacological properties. Hosp Chron. 2006;Suppl 1:151-5. 29. DiFrancescoD, Tortora P. Direct activation of cardiac pacemaker channels by intracellular cyclic AMP. Nature. 1991;351(6322):145-7. 30. El-Mosallamy AE, SleemAA, Abdel-Salam OM, Shaffie N, Kenawy SA. Antihypertensive and cardioprotective effects of pumpkin seed oil. J Med Food. 2012;15(2):180-9. 31. Fish JM, Di Diego JM, Nesterenko V,Antzelevitch C. Epicardial activation of left ventricular wall prolongs QT interval and transmural dispersion of repolarization: implications for biventricular pacing. Circulation. 2004;109(17):2136-42. 32. Feldman J, Goldwasser GP. Electrocardiogram: recommendations for interpretation. Rev. SOCERJ. 2004;17(4):251-6. 33. Nicolau JC, Polanczyk CA, Pinho JA, Bacellar MSC, Ribeiro DGL, Darwich RN, et al. Diretriz de interpretação de eletrocardiograma de repouso. Arq Bras Cardiol. 2003;80(supl II):1-18. 34. Verweij N, Leach IM, van den Boogaard M, van Veldhuisen DJ, Christoffels VM, Hillege HL, et al. Genetic determinants of P wave duration and PR segment. Circ Cardiovasc Genet. 2014;7(4):475-81. 35. Hazari MS, Haykal-Coates N, Winsett DW, Costa DL, Farraj AK. Continuous electrocardiogram reveals differences in the short-term cardiotoxic response of Wistar-Kyoto and spontaneously hypertensive rats to doxorubicin. Toxicol Sci. 2009:110(1):224-34. 36. Hazari MS, Haykal-Coates N, Winsett DW, Costa DL, FarrajAK.A single exposure to particulate or gaseous air pollution increases the risk of References Vertamatti AG, Borghi F, Ramos LA, Areas MA, Grassi- Kassisse DM. Statistical analysis: Conceição-Vertamatti AG, Borghi F, Grassi-Kassisse DM. Obtaining financing: Grassi-Kassisse DM. Writing of the manuscript: Conceição-Vertamatti AG, Borghi F, Ishizu LY, Costa GT, Grassi-Kassisse DM. Critical revision of the manuscript for intellectual content: Conceição-Vertamatti AG, Borghi F, Areas MA, Grassi-Kassisse DM. Grassi-Kassisse et al. ECG in hypertension models Int J Cardiovasc Sci. 2020; 33(4):321-328 Original Article