IJCS | Volume 33, Nº4, July and August 2020

317 Study Did the patient(s) represent the whole case(s) of the medical center Was the diagnosis correctly made Were other important diagnosis excluded Were all important data cited in the report Was the outcome correctly ascertained Global quality assessment CLOSURE 1 Yes Yes Yes Yes Yes Good RESPECT Yes Yes Yes Yes Yes Good PC TRIAL Yes Yes Yes Yes Yes Good CLOSE Yes Yes Yes Yes Yes Good REDUCE Yes Yes Yes Yes Yes Good DEFENSE PFO Yes Yes Yes No Yes Moderate Pereira et al. Patent foramen ovale in cryptogenic stroke Int J Cardiovasc Sci. 2020; 33(4):307-317 Original Article Supplementary file 2 Article quality assessment according to the method used by Haffar et al. For acronyms and complete references see text. This is an open-access article distributed under the terms of the Creative Commons Attribution License Supplementary file 1 Search strategy: 1. Medline (PubMed) database - query “patent foramen ovale” AND “stroke” AND “closure” with the filter “clinical trial”. 2. ISI Web of Knowledge - query “patent foramen ovale”AND “stroke”AND “closure” with the filter “article”.