IJCS | Volume 33, Nº4, July and August 2020

316 cryptogenic stroke — An updated comprehensive meta-analysis. Cardiovasc Revascular Med. 2019;20(8):687-94. 15. Ma Y, Li D, Bai F, Qin F, Li J, Li Y, et al. Patent foramen ovale closure or medical therapy for secondary prevention of cryptogenic stroke: An update meta-analysis of randomized controlled trials. Medicine (Baltimore). 2018;97(34):e11965. 16. Vukadinovic D, Schirmer SH, Vukadinovic AN, Ukena C, Scheller B, Mahfoud F, et al. Interventional closure vs. medical therapy of patent foramen ovale for secondary prevention of stroke: updatedmeta-analysis. Clin Res Cardiol. 2019;108(2):157-66. 17. Qiu B, Cai Y, Wang D, Lin J, Fan Y. Closure versus Medical Therapy for Patent Foramen Ovale in Patients with Cryptogenic Stroke: An Updated Meta-Analysis of Randomized Controlled Trials. J Stroke Cerebrovasc Dis. 2018;27(12):3463-72. 18. Lattanzi S, Brigo F, Cagnetti C, Di Napoli M, Silvestrini M. Patent Foramen Ovale and Cryptogenic Stroke or Transient Ischemic Attack: To Close or Not to Close? A Systematic Review and Meta-Analysis. Cerebrovasc Dis. 2018;45(5-6):193-203. 19. Turc G, Calvet D, Guerin P, Sroussi M, Chatellier G, Mas JL, et al. Closure,Anticoagulation, orAntiplatelet Therapy for Cryptogenic Stroke With Patent Foramen Ovale: Systematic Review of Randomized Trials, Sequential Meta-Analysis, and New Insights From the CLOSE Study. J Am Heart Assoc. 2018;7(12).piie00356 20. Haffar S, Shalimar, Kaur RJ, Wang Z, Prokop LJ, MuradMH, et al. Acute liver failure caused by hepatitis E virus genotype 3 and 4: A systematic review and pooled analysis. Liver Int. 2018;38(11):1965-73. 21. Hara H, Virmani R, Ladich E, Mackey-Bojack S, Titus J, Reisman M, et al. Patent Foramen Ovale: Current Pathology, Pathophysiology, and Clinical Status. J Am Coll Cardiol. 2005;46(9):1768-76. 22. Diener HC, Gerloff C, Thaler DE, Wohrle J. Closure of Patent Foramen Ovale and Cryptogenic Stroke: Unresolved Issues. Curr Neurol Neurosci Rep. 2018;18(12):92. Pereira et al. Patent foramen ovale in cryptogenic stroke Int J Cardiovasc Sci. 2020; 33(4):307-317 Original Article