IJCS | Volume 33, Nº3, May / June 2020

260 Silva et al. Polymorphisms in acute coronary syndrome Int J Cardiovasc Sci. 2020; 33(3):254-262 Original Article Table 4 – Distribution of genotypic frequencies of SNPs in IL8 and IL16 genes in different healthy populations SNP Country N Genotype frequencies n (%) p Reference AA AT TT IL8 (rs4073) Brazil (Northeast*) 220 61 (27.8) 111 (50.4) 48 (21.5) 1 - Brazil (Maranhão) 97 22 (22.7) 46 (47.4) 29 (29.9) 0.28 Frade et al., 2011 20 Brazil (São Paulo) 126 38 (30.2) 65 (51.6) 23 (18.2) 0.71 Matos et al., 2011 21 Hungary 75 15 (20.0) 30 (40.0) 30 (40.0) 0.01 Farkas Jr et al., 2011 25 China 636 80 (12.6) 292 (45.9) 264 (41.5) < 0.0001 Zhang et al., 2011 6 Turkey 38 8 (21.0) 11 (29.0) 19 (50.0) 0.002 Cengiz et al., 2014 26 Iran 40 12 (30.0) 17 (42.5) 11 (27.5) 0.62 Khosropanah et al., 2013 22 United Kingdom 235 54 (23) 105 (44.7) 76 (32.3) 0.03 Smith et al., 2004 27 Greece 126 38 (30.2) 65 (51.6) 23 (18.2) 0.71 Georgitsi et al., 2016 9 TT TG GG IL16 (rs11556218) Brazil (Northeast*) 220 141 (64.0) 78 (35.5) 1 (0.5) 1 China 402 235 (58.4) 151 (37.6) 16 (4.0) 0.01 Tang et al., 2016 23 Iran 144 81 (56.3) 48 (33.3) 15 (10.4) < 0.0001 Azimzadeh et al, 2016 28 N: number of individuals; * Present study; p: p-value (G of Williams) Brazilian populations, it can be interpreted that despite the intense miscegenation in the country, the genetic characteristics in relation to the SNP evaluated, have been conserved in these populations. Regarding the SNP in the IL16 gene, no similarities were foundwhen comparing the frequencies of our study with other populations. The genotypic variety found in the comparison between the results of the present study and other countries leaves us the important observation that further population studies should be carried out in order to understand these similarities or differences found. Conclusions The mutant G allele of rs11556218 polymorphism in the IL-16 gene presents a possible protective action in relation to the development of ACS in the studied population. Regarding the SNP rs4073 (IL8), no association was found with SCA. The comparison between the frequency of the SNPs rs4073 (IL8) and rs11556218 (IL16) of the present study and other world populations demonstrated a wide genetic variety.