IJCS | Volume 33, Nº3, May / June 2020

259 Silva et al. Polymorphisms in acute coronary syndrome Int J Cardiovasc Sci. 2020; 33(3):254-262 Original Article Figure 1 – Box-plot (median and quartiles) of IL-16 dosages in patients with ACS and healthy individuals in different IL16 genotypes. Box-plot (median and quartiles) of IL-16 dosages in patients with ACS and blood donors in different IL16 genotypes. A) Median IL-16 in blood donors (TT = 447.7 pg/mL; TG + GG = 709.2 pg/mL, p = 0.001); B) Median of IL-16 in patients with ACS (TT = 381.4 pg/ml; TG + GG = 314.9 pg/ml, p = 0.288); C) Median IL-16 in blood donors (563.0 pg/mL) and patients with ACS (355.4 pg/ mL) (p = 0.04); p = Mann-Whitney. is that the SNP in the IL16 gene (rs11556218) is involved with CDs in general, not only with ACS, and further studies are needed, with different populations to answer this question. An a s s oc i a t i on wa s f ound r ega rd i ng t he polymorphism in IL16 gene (rs11556218) and the risk factors hypertension and dyslipidemia. These results corroborate the data found by Chen et al., 7 with 300 patients withACS who showed a significant association between the homozygous variant (GG) genotype and the hypertension, diabetic and smoker individuals. In addition, the study by Wu et al., 15 with 326 Chinese patients withACS also found an association between the GG genotype and the disease in hypertensive, diabetic, smoker, obese and dyslipemic individuals. The analysis of the frequencies of polymorphisms in genes of medical interest for a disease in a population can become an important tool to understand and evaluate the risks that this disease can bring, as well as its morbidity and mortality. The results can be used in future studies of association between these polymorphisms and different pathologies. Thus, the present study also evaluated a comparison between the frequencies of polymorphisms in the IL8 and IL16 genes of our healthy, blood donor individuals with several other healthy populations from other countries. Regarding the IL8 polymorphism, a similarity was observed in the genotypic distributionwith two Brazilian populations (Maranhão and São Paulo) and two from other countries (Iran and Greece). With respect to the