IJCS | Volume 33, Nº3, May / June 2020

241 1. Torrati F, Dantas R. Extracorporeal circulation and complications during the immediate postoperative period for cardiac surgery. Acta Paul Enferm. 2012;25(3):340-5. 2. Dobrovolskaia MA, McNeil SE. Safe anticoagulation when heart and lungs are “on vacation”. Ann Transl Med. 2015;3(S1):S11. 3. Aquino RS, Pereira MS, Vairo BC, Cinelli LP, Santos GR, Fonseca RJ, et al. Heparins fromporcine and bovine intestinal mucosa: are they similar drugs? Thromb Haemost. 2010;103(5):1005-15. 4. Fu L, Li G, Yang B, Onishi A, Li L, Sun P, et al. Structural characterization of Pharmaceutical heparins prepared from different animal tissues. J Pharm Sci. 2013;102(5):1447-57. 5. Junqueira DR, Viana TG, Peixoto ER, Barros FC, Carvalho Md, Perini E. Heparin pharmacovigilance in Brazil. Rev Assoc Med Bras. 2011; 57(3):322-26. 6. Santos GR, Tovar AM, Capillé NV, Pereira MS, Pomin VH, Mourão PA. Structural and functional analyses of bovine and porcine intestinal heparins confirm they are different drugs. 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Thrombocytopenia in cardiac surgery: diagnostic and prognostic importance. Rev Bras Cir Cardiovasc. 2001;26(1):47-53. 18. Cuker A. Clinical and Laboratory Diagnosis of Heparin-Induced Thrombocytopenia: An Integrated Approach. Semin Thromb Hemost. 2014;40(1):106-14. 19. Salis S, Mazzanti VV, Merli G, Salvi L, Tedesco CC, Veglia F, et al. Cardiopulmonary bypass duration is an independent predictor of morbidity and mortality after cardiac surgery. J Cardiothorac Vasc Anesth. 2008;22(6):814-22. 20. Miana LA, Atik FA, Moreira LF, Hueb AC, Jatene FB, Auler Jr JO, et al. Risk factors for postoperative bleeding after adult cardiac surgery. Braz J Cardiovasc Surg. 2004;19(3):280-86. 21. Kouchoukos NT, Blackstone EH, Doty DB, Hanley FL, Karp RB. Hypothermia, circulatory arrest and cardiopulmonary bypass. In: Kirklin/Barratt-Boyes Cardiac Surgery: Morphology, Diagnostic Criteria, Natural History, Techniques, Results and Indications, ed. Karp Elsevier Science, 3rd ed. PA: Churchill Livingstone; 2003:p.67-132. 22. Baugham DR, Woodward PM. A collaborative study of heparin from different sources. Bull Wid Hith Org.1970; 42(1):129-49. 23. Fiser WP, Read RC, Wright FE, Vecchio TJ. A randomized study of beef lung and pork mucosal heparin in cardiac surgery. Ann Thorac Surg. 1983;35(6):615-20. 24. Effeney DJ, Goldstone J, Chin D, Krupski WC, Ellis RJ. Intraoperative anticoagulation in cardiovascular surgery. Surgery. 1981;90(6):1068-74. 25. Sklehan TM, Heflin DW. Optimal ACT sampling interval in pediatric and adult patients after systemic heparinization. Anesthesiology. 1989;71(Suppl 3A):289. References Lima et al. Unfractionated bovine heparin safety Int J Cardiovasc Sci. 2020; 33(3):235-242 Original Article Torres ACB, Cordeiro TMG. Statistical analysis: Torres FAL. Obtaining financing: Torres FAL. Writing of the manuscript: Torres FAL, Torres ACB, Cordeiro TMG. Critical revision of themanuscript for intellectual content: Torres FAL, Cordeiro TMG. Potential Conflict of Interest No potential conflict of interest relevant to this article was reported. Sources of Funding There were no external funding sources for this study. Study Association This study is not associated with any thesis or dissertation work. Ethics approval and consent to participate This study was approved by the Ethics Committee of the Faculdade Sant´Ana – Ponta Grossa, PR under the protocol number 1844221/2016. All the procedures in this study were in accordance with the 1975 Helsinki Declaration, updated in 2013. Informed consent was obtained from all participants included in the study.

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