IJCS | Volume 33, Nº3, May / June 2020

237 Table 1 - Demographic data and clinical characteristics of the study population Bovine UFH treated N = 204 Porcine UFH treated N = 65 Total N = 269 Gender Male 132 (64.71) 37 (56.92) 169 (62.83) Female 72 (35.29) 28 (43.08) 100 (37.17) Age (years) Median 61.4 61.8 61.6 (Min-max) (16.8-87.0) (18.1-77.1) (16.8-87.0) Weight (kg) Median 72.5 73.0 73.0 (Min-max) (43.0-130.0) (50.3-113.0) (43.0-130.0) Main comorbidities Hypertension 150 (73.53) 51(78.43) 201 (74.72) Diabetes mellitus 55 (26.96) 24 (36.92) 79 (29.37) Dyslipidemia 9 (4.41) 11 (16.92) 20 (7.43) Main surgical indication Coronary artery insufficiency 134 (65.69) 39 (60.0) 173 (64.31) Aortic stenosis 22 (10.78) 16 (24.62) 38 (14.13) Aortic valve insufficiency 25 (12.25) 10 (15.38) 35 (13.01) Mitral valve insufficiency 27 (13.24) 5 (7.69) 32 (11.90) Cardiac aneurysm 15 (7.35) 5 (7.69) 20 (7.43) Acute myocardial infarction 12 (5.88) 2 (3.08) 14 (5.20) Qualitative variables are shown as n (%) and quantitative variables as median and minimum and maximum values. Source: prepared by the authors. Lima et al. Unfractionated bovine heparin safety Int J Cardiovasc Sci. 2020; 33(3):235-242 Original Article Data from bovine and porcine heparin are presented in the Tables together; however, we did not compare the groups since it was not the study objective. Male patients were more than half, with median age of 61.6 years and approximately 46%presented comorbidity. Hypertensionwas themost frequent comorbidity, followed by diabetes mellitus and dyslipidemia. Coronary artery insufficiency was the primary cause of the cardiovascular diagnoses that led to the surgical procedure (Table 1). As shown in Table 2, more than 50% of the surgeries were coronary artery bypass grafting followed by aortic valve replacement. Median surgery duration was 297.5 minutes, of which ECC was 89.0 minutes. Safety outcomes of bovine UFH patients From the 269 medical records evaluated of patients treated with bovine UFH, the median bleeding for 24h of the postoperative period was 545 mL. Two patients (1.04%) showed bleeding of more than 2000mL in the first 24 hours (Table 3). The incidence of thrombocytopenia was 66.18%. The need for surgical re-exploration (by bleeding or tamponade) occurred in 0.98%of the patients. No patient presented vasoplegia. One patient presented clots in the surgical field during ECC. He also presented intraoperative thrombosis of vascular grafts. Safety outcomes of porcine UFH patients Median bleeding after 24h was 400 mL. Two (3.07%) participants treated with porcine UFH showed bleeding of more than 2,000 mL (Table 3). Thrombocytopenia occurred in 83.08% of the patients, and surgical re- exploration was required (by bleeding or tamponade) in 3.07%. One patient presented vasoplegia, and another one had clots in the surgical field during ECC.