IJCS | Volume 33, Nº2, March / April 2020

DOI: 10.5935/2359-4802.20190079 112 ORIGINAL ARTICLE International Journal of Cardiovascular Sciences. 2020; 33(2):112-118 Mailing Address: Beatriz Pinto e Siqueira Campos Universidade Federal da Paraíba - Centro de Ciências Médicas (CCM) - Cidade Universitária, s/n. Postal code: 58051-085, Castelo Branco III, João Pessoa, PB - Brazil. E-mail: beatrizsiqueirajp@gmail.com Cardiovascular Risk Factors and Risk Measurement in Patients with Psoriatic Arthritis in a University Hospital Beatriz Pinto e Siqueira Campo s, G ustavo Daniel dos Santos Gome s, Alessandra de Sousa Bra z, A ndre Telis de Vilel a Universidade Federal da Paraíba - Centro de Ciências Médicas (CCM), João Pessoa, PB - Brazil Manuscript received on March 18, 2019; reviewed on March 27,2019; accepted on April 03, 2019. Abstract Background: Psoriatic Arthritis is the spondyloarthritis associated with psoriasis, which is often related to high mortality due to cardiovascular causes. Objectives: To quantify cardiovascular risk factors (hypertension, diabetes, dyslipidemia, obesity and smoking) and to measure risk by the Global Cardiovascular Risk Score in patients with psoriatic arthritis. Methods: Patients with psoriatic arthritis according to the Classification Criteria for Psoriatic Arthritis, aged between 30 and 74 years and without any other clinically manifest chronic inflammatory disease, atherosclerotic disease or heart failure were included. After an interview, clinical examination and data extraction from medical records, risk stratification was performed using a calculator available on the online platform of the Framingham Heart Study. We considered p < 0.05 as significant. Chi-square test and Fisher’s exact test were used to compare frequencies, as well as correlation measurements. Results: 45 patients were included, 68,9% of which were women and the mean age was 53,94 years. Dyslipidemia was confirmed in approximately 93%, hypertension in 46%, obesity in 40%, 33.3% were diabetics and, 13.3%, smokers; 95% had increased abdominal circumference. It was observed that 53% had high cardiovascular risk, 29% had intermediate risk and 18% had low risk. Individuals with altered C-reactive protein and erythrocyte sedimentation rate presented, respectively, higher levels of LDL-C and total cholesterol. Conclusions: There was a high occurrence of risk factors and the majority of the sample was stratified into high or intermediate cardiovascular risk. (Int J Cardiovasc Sci. 2020; 33(2):112-118) Keywords: Cardiovascular Diseases; Risk Factors; Obesity; Dyslipidemias; Inflammation; Arthritis, Psoriatic. Introduction Psoriasis is a chronic immune-mediated inflammatory disease, which classically involves the skin and affects 1.3% of the Brazilian population. 1-3 Psoriatic arthritis (PsA) is an inflammatory joint pathology that occurs in association with psoriasis, present in 10 to 30% of those with cutaneous manifestations. 4,5 The course of PsA ranges from mild manifestations to a debilitating picture. Skin injuries usually precede arthropathy and severity of cutaneous disease is unrelated to joint disease activity. 6 Its pathogenesis is not well established, but genetic, immunological, environmental factors — infections and traumas —obesity and smoking are likely to be involved. 7-14 The CASPAR (Classification Criteria for Psoriatic Arthritis) criteria are those recommended by the Brazilian Society of Rheumatology for PsA classification and diagnosis. It takes into account the presence of inflammatory joint disease associated with some of the following: current psoriasis, personal or family history of psoriasis, dactylitis, juxta-articular bone formation (in hands or feet), negative rheumatoid factor and psoriasis