IJCS | Volume 33, Nº1, January / February 2019

89 Table 1 - Characteristics of the studies on single photon emission computed tomography using radiolabelled white blood cell and infectious endocarditis Author Year Design study N pts Clinical setting Sensitivity Specificity Accuracy Diagnostic criteria Reference standard Erba et al. 2012 Retrospective 51 16 NVE, 35 PVE 90% nr 90% Visual analysis Microbiological analysis or clinical follow-up Hyafil et al. 2013 Retrospective 42 42 PVE nr 100% nr Visual analysis Pre-operative macroscopic analysis and bacteriological analysis + clinical follow-up Rouzet et al. 2014 Retrospective 39 39 PVE 65% 100% 86% Visual and semiquantitative analysis Combination of modified Duke criteria and clinical follow-up Caobelli et al. 2017 Retrospective 34 12 NVE, 22 PVE 86% 95% 91% Visual analysis Microbiological analysis + combination of modified Duke criteria and clinical follow-up NVE: native valve endocarditis; PVE: prosthetic valve endocarditis; nr: not reported. Figure 1 - Flow-chart of the search strategy. 665 abstracts identified by search algorithm 20 articles screened in full-text version - 4 on WBC SPECT/CT - 16 on 18F-FDG PET/CT Albano et al. PET and SPECT in endocarditis Int J Cardiovasc Sci. 2020;33(1):87-93 Review Article