IJCS | Volume 33, Nº1, January / February 2019

DOI: 10.5935/2359-4802.20190029 Introduction Cardiovascular diseases are the main causes of morbidity andmortality in the world population. Due to aging of the global population, cardiovascular diseases, mainly represented by coronary artery disease (CAD), play an incremental role on global mortality. 1 In this context, changes in lifestyle have contributed to increased incidence of cardiovascular risk factors and ultimately of coronary disease. Due to its increasing incidence on a global scale (39% of adults aged 18 years and older are obese), obesity has become one of the factors with the greatest impact on the risk of CAD. 2 Obesity is recognized as one of the most important underlying risk factors for a wide variety of metabolic diseases, such as hypertension, dyslipidemia, and diabetes, which are strongly associated with the development of cardiovascular diseases. 3 Nevertheless, whether obesity alone is a risk factor for CAD has not been well established. 4-6 In this regard, the phenotype 57 ORIGINAL ARTICLE International Journal of Cardiovascular Sciences. 2020;33(1):57-64 Mailing Address: Tiago Magalhaes Rua Moysés Marcondes, 181, ap 501. Postal Code: 80030-410, Juveve, Curitiba, PR - Brazil. E-mail: tiaugusto@gmail.com , taugusto@cardiol.br Relationship between Obesity and Coronary Artery Disease Defined by Coronary Computed Tomography Angiography Lara Luiza Silvello Pereira, 1 G isele Marochi de Moraes, 1 A driano Camargo de Castro Carneiro, 2 Valéria de Melo Moreira, 2 Juliana Hiromi Silva Matsumoto Bello, 2 C arlos Eduardo Elias dos Prazeres, 2 C arlos Eduardo Rochitte, 2 T iago Magalhaes 2 Pontifícia Universidade Católica do Paraná (PUCPR), 1 Paraná, PR - Brazil HCOR, 2 São Paulo, SP - Brazil Manuscript received March 22, 2018; revised manuscript August 27, 2018; accepted September 03, 2018. Abstract Background: Although associated with traditional cardiovascular risk factors, it is unclear whether obesity alone is associated with coronary artery disease (CAD). Objective: To investigate the role of obesity as a risk factor for CAD, defined by coronary computed tomography angiography (CCTA). Methods: This study retrospectively included 1,814 patients referred for CCTA in a hospital in São Paulo, from August 2010 to July 2012. CAD was identified by coronary calcium score and presence of coronary stenosis > 50%. Images were analyzed by two specialists, and the coronary findings were compared between obese and non-obese groups. A multivariate analysis model was used to assess obesity as an independent variable for the occurrence of obstructive CAD. Results: Among the study population, mean age was 58.5 +/- 11.5 years, 22.8% were obese (BMI = 30 kg/m 2 ) and 66.3% were male. The prevalence of obstructive CAD was 18.4% in both groups. Obese patients had higher median calcium score compared to non-obese subjects (14.7 vs. 1.4, respectively, p = 0.019). In the multivariate analysis, obesity was not an independent factor for obstructive CAD (coefficient = -0.035, p = 0.102). Conclusion: Although no differences were observed in the prevalence of obstructive CAD between obese and non-obese individuals, coronary calcium scores were significantly in lower the latter group. (Int J Cardiovasc Sci. 2020;33(1):57-64) Keywords: Coronary Artery Disease; Obesity; Body Mass Index; Dyslipidemias; Risk Factors; Prevalence; Tomography/métodos; Coronary Angiography/methods.