IJCS | Volume 33, Nº1, January / February 2019

96 Costa et al. Takotsubo syndrome versus transmural acute myocardial infarction Int J Cardiovasc Sci. 2020;33(1):94-97 Brief Communication number of patients, although inherent to the low prevalence of this condition, limits the drawing of conclusions. On the other hand, our focus on patients suspected of STEMI is a strength of our study. In Brazil, future studies with clinical follow-up that include a large number of patients of this subgroup and analyze data from multicenter registries are necessary to increase the knowledge of TTS. Conclusions The prevalence of TTS among patients initially suspected of STEMI was 3.2%. The clinical profile of TTS differed from that of STEMI in that it was more prevalent in women and was associated with emotional and/or physical stress, neuropsychiatric disorders, lower Table 1 - Comparison of demographic and clinical variables between patients diagnosed with Takotsubo syndrome and acute myocardial infarction* Characteristic Takotsubo syndrome (n = 6) Acute myocardial infarction (n = 24) p value † Age, years 72.5 ± 7.2 65.3 ± 13.3 0.109 Female, n (%) 6 (100%) 8 (33.3%) 0.003 Isolated chest pain, n (%) 2 (33.3%) 14 (58.3%) 0.025 Emotional and/or physical stress, n (%) 3 (50.0) 3 (12.5%) 0.040 InterTAK score 60.5 (43.0 – 67.0) 24.0 (18.0 – 39.5) < 0.001 Heart rate, bpm 74 (68 – 84) 74 (65 – 83) 0.667 Systolic blood pressure, mmHg 128 (113 – 145) 140 (112 – 158) 0.672 Body mass index, kg/m² 22.85 (21.9 – 27.1) 28.40 (24.9 – 29.4) 0.050 QTc interval, ms 516.5 (475.0 – 550.0) 452 (429.0 – 468.5) 0.010 Peak troponin value, ng/mL 2.2 (0.69 – 3.66) 9.43 (3.19 – 30.00) 0.033 Peak CK-MB value, ng/mL 9.65 (4.40 – 24.60) 46.75 (14.35 – 80.00) 0.065 Left ventricular ejection fraction, % ‡ 35.5 (30.0 – 40.0) 56.0 (45.0 – 64.0) 0.018 Coronary artery disease, n (%) 3 (50.0%) 24 (100%) < 0.001 Systemic arterial hypertension, n (%) 3 (50.0%) 18 (75.0%) 0.232 Smoker, n (%) 0 (0%) 2 (8.3%) 0.208 Diabetes mellitus, n (%) 0 (0%) 8 (33.3%) 0.099 Dyslipidemia, n (%) 5 (83.3%) 11 (45.8%) 0.100 Neuropsychiatric disorders, n (%) 3 (50.0%) 3 (12.5%) 0.040 * Continuous data are presented as mean ± standard deviation (parametric) or as median (interquartile range) (non-parametric); † Means were compared using the Student’s t-test, medians using the Mann–Whitney test, and percentages using the Pearson’s chi-square test; ‡ Left ventricular ejection fraction was calculated from echocardiogram results. ejection fraction, lower peak troponin levels, and higher InterTAK scores. Author contributions Conception and design of the research: Costa JPS, Ritt LEF, Campos FAD, DarzéES.Acquisitionof data: Costa JPS, Ritt LEF, Campos FAD, Borges Q, Darzé ES. Analysis and interpretation of the data: Costa JPS, Ritt LEF, Fernandes RM, Campos FAD, Borges Q, Darzé ES. Statistical analysis: Costa JPS, Ritt LEF, Fernandes RM, Borges Q, Darzé ES. Obtaining financing: Costa JPS, Ritt LEF, Borges Q, Darzé ES. Writing of the manuscript: Costa JPS, Ritt LEF, Fernandes RM, Borges Q, Darzé ES. Critical revision of the manuscript for intellectual content: Costa JPS, Ritt LEF, Fernandes RM, Campos FAD, Borges Q, Darzé ES.