IJCS | Volume 32, Nº6, November / December 2019

570 Table 4 - Predictors of transfusion in univariate and multivariate analyses Univariate analysis Variable Odds ratio 95% confidence interval p value Emergency or urgency surgery 3.1 1.8 – 5.2 < 0.001 Previous cardiac surgery 3.5 1.4 – 8.2 0.004 EuroScore II 1.2 1.1 – 1.3 < 0.001 Chronic kidney disease 3.9 1.9 – 8.1 < 0.001 Left ventricular ejection fraction ≤ 30% 3.5 1.4 – 1.8 0.005 Preoperative hemoglobin ≤ 10 g/dL 27 6.3 – 362 < 0.001 Preoperative INR 17.5 3.1 – 97 0.001 Preoperative aPTT 1.1 1.0 – 1.2 < 0.001 Preoperative urea 1.02 1.01 – 1.03 < 0.001 Preoperative creatinine 1.8 1.1 – 2.9 0.008 Combined surgery 2.6 1.3 – 5.0 0.003 Cardiopulmonary bypass time 4.8 2.8 – 8.2 < 0.001 Cross-clamp time 4.8 2.8 – 8.2 < 0.001 Transoperative bleeding ≥ 500 mL 9.6 4.6 – 20 < 0.001 Multivariate analysis EuroScore II 1.2 1.0 – 1.3 0.019 Chronic kidney disease 3.2 1.0 – 11 0.05 Preoperative hemoglobin ≤ 10 g/dL 11.5 1.0 – 121 0.04 Preoperative aPTT 1.1 1.0 – 1.2 0.012 Cardiopulmonary bypass time 1.03 1.01 – 1.06 0.004 Transoperative bleeding ≥ 500 mL 6.7 2.6 – 17 < 0.001 EuroSCORE II: European System for Cardiac Operative Risk Evaluation; INR: international normalized ratio; aPTT: activated partial thromboplastin time; P-value was obtained by logistic regression. Tagliari et al. Blood transfusion in cardiovascular surgery Int J Cardiovasc Sci. 2019;32(6):565-572 Original Article aPTT values and duration of cardiopulmonary bypass showed independent predictors for blood transfusion, which was associated with postoperative adverse outcomes, including early mortality. Author contributions Conception and design of the research: Tagliari AP, Cavazzola LT, Wender OCB. Acquisition of data: Tagliari AP, Silveira LMV, Souza AC, Gib MC, Freitas TM, Martins CB. Analysis and interpretation of the data: Tagliari AP, Kochi AN, Cavazzola LT, Wender OCB. Statistical analysis: Tagliari AP, Kochi AN. Writing of the manuscript: Tagliari AP, Silveira LMV, Kochi AN. Critical revision of themanuscript for intellectual content: Tagliari AP, Silveira LMV, Kochi AN, Souza AC, GibMC, Freitas TM, Martins CB, Cavazzola LT, Wender OCB. Potential Conflict of Interest No potential conflict of interest relevant to this article was reported.