IJCS | Volume 32, Nº5, September/October 2019

513 Table 5 - Differences in means of echocardiographic parameters as markers of minor diastolic dysfunction according with the presence of Hypovitaminosis D Parameters measured by echo-Doppler Hypovitaminosis D L E (cm/s) Yes 64,85 ± 1,1 No 66,86 ± 0,9 A (cm/s) Yes 70,32 ± 1,36 No 67,6 ± 1,07 E/A Yes 0,98 ± 0,02*** No 1,07 ± 0,02 *** P value of t tests < 0.01 Table 6 - Difference in means of echocardiographic parameters as indicators of major diastolic dysfunction that indicate remodeling according with the presence of Hypovitaminosis D Parameters measured by echo- Doppler Hypovitaminosis D LVM (g) Yes 163,05 ± 2,71 No 156,25 ± 2,35 LVMi (g/m 2 ) Yes 91,05 ± 1,43 No 91,14 ± 1,24 EDV (ml) Yes 110,49 ± 1,48 No 109,79 ± 1,27 EDVi (ml/m 2 ) Yes 75,46 ± 1,15 No 74,98 ± 0,97 SV (ml) Yes 61,89 ± 0,81 ** No 64,27 ± 0,69 IVS (mm) Yes * 8,08 ± 0,08 ** No 7,86 ± 0,07 RWT Yes 0,33 ± 0 * No 0,32 ± 0 LVPWT Yes * 7,95 ± 0,07 ** No 7,7 ± 0,06 LVEDD Yes *** 61,89 ± 0,81 ** No 64,27 ± 0,69 *P value of t tests ≥ 0.05 and < 0.1; ** P value of t tests ≥ 0.01 and < 0.5; ***P value of t tests < 0.01. Table 7 - Differences in means of echocardiographic parameters as markers of systolic dysfunction according with the presence of Hypovitaminosis D Parameters measured by echo-Doppler Hypovitaminosis D SEF (%) Yes 61,56 ± 0,37 No 61,55 ± 0,32 S (cm/s) Yes 8,36 ± 0,12 No 8,36 ± 0,1 in Table 6. Parameters of cardiac (ventricular) geometry (IVS, RWT, LVPWT and LVEDD) were associated with the presence of hypovitaminosis D. There was no difference in mean values of echocardiographic parameters, which assessed t he sys t o l i c f unc t i on f r om t he pr e s enc e o f hypovitaminosis D. Both ejection fraction and analysis by Tissue Doppler Imaging (S wave) did not reveal any abnormalities that could represent systolic dysfunction (Table 7). Discussion This study examined the risk of diastolic dysfunction (DD) in a population with hypovitaminosis D, using a marker to assess the vitamin D nutritional status and tissue Doppler echocardiography to evaluate parameters of systolic and diastolic function. In our study, we investigated whether the patients who had hypovitaminosis D would be associated with diastolic dysfunction, andwe observed that DDwasmore prevalent among these individuals. We noted that both indexed (i) LV diameter and volume (a diastolic dysfunction marker) were strongly associated with the presence of diastolic dysfunction, and identified by echocardiography. In accordance with our study, Rahman et al., 17 have concluded that Vitamin D reduction (< 20 ng/ml) seems to be correlated with worsened systolic function in terms of end-systolic volume and end-systolic dimension. 17 Macedo et al. Increased left atrial volume Int J Cardiovasc Sci. 2019;32(5):508-516 Original Article