IJCS | Volume 32, Nº2, May/June 2019

267 1. Moran AE, Forouzanfar MH, Roth GA, Mensah GA, Ezzati M, Murray CJ, et al. Temporal trends in ischemic heart disease mortality in 21 world regions, 1980 to 2010: the Global Burden of Disease 2010 Study. Circulation. 2014;129(14):1483-92. 2. Brasil.Ministério da Saúde Secretaria Executiva. Departamento de Informática do DATASUS. Informações de saúde. Morbidade e informações epidemiológicas. Brasília (DF);2010. [citado 2016 nov 16]. Disponível em: www2datasus.gov.br/DATASUS/indexphp?area=0203. 3. Mack M, Gopal A. Epidemiology, traditional and novel risk factors in coronary artery disease. Cardiol Clin. 2014;32(3):323-32. 4. O'Keefe JH, Bybee KA, Lavie CJ. Alcohol and cardiovascular health: the razor-sharp double-edged sword. J AmColl Cardiol. 2007;50(11):1009-14. 5. Hvidtfeldt UA, Tolstrup JS, Jakobsen MU, Heitmann BL, Grønbaek M, O'Reilly E, et al. Alcohol intake and risk of coronary heart disease in younger, middle-aged, and older adults. Circulation. 2010;121(14):1589-97. 6. 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Clinical predictors of early infarct-related artery patency following thrombolytic therapy: importance of body weight, smoking history, infarct- related artery and choice of thrombolytic regimen: the GUSTO-I experience. J Am Coll Cardiol. 1998;32(3):641-7. 24. Gurbel PA, Bliden KP, Logan DK, Kereiakes DJ, Lasseter KC, White A, et al. The influence of smoking status on the pharmacokinetics and pharmacodynamics of clopidogrel and prasugrel: the paradox study. J Am Coll Cardiol. 2013;62(6):505-12. 25. Ferreiro JL, Bhatt DL, UenoM, Bauer D, Angiolillo DJ. Impact of smoking on long-term outcomes in patients with atherosclerotic vascular disease treated with aspirin or clopidogrel: insights from the CAPRIE trial (clopidogrel versus aspirin in patients at risk of ischemic events). J Am Coll Cardiol. 2014;63(8):769-77. 26. Gupta T, Kolte D, Khera S, Harikrishnan P, Mujib M, Aronow WS, et al. Smoker’s paradox in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. J Am Heart Assoc. 2016;5(4): e003370. 27. Skliros EA, Papadodima SA, Sotiropoulos A, Xipnitos C, Kollias A, Spiliopoulou CA. Relationship between alcohol consumption and control References Albuquerque et al. Association smoking and alcohol consumption AMI Int J Cardiovasc Sci. 2019;32(3)261-268 Original Article Sources of Funding There were no external funding sources for this study. Study Association This article is part of the thesis of course completion submitted by Luis Gustavo Albuquerque, from Universidade do Sul de Santa Catarina . Ethics approval and consent to participate This study was approved by the Ethics Committee of the Instituto de Cardiologia de Santa Catarina under the protocol number 1.519.838. All the procedures in this study were in accordance with the 1975 Helsinki Declaration, updated in 2013. Informed consent was obtained from all participants included in the study.

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