IJCS | Volume 32, Nº2, May/June 2019

252 experimentação, a produção, a embalagem e rotulagem, o transporte, o armazenamento, a comercialização, a propaganda comercial, a utilização, a importação, a exportação, o destino final dos resíduos e embalagens, o registro, a classificação, o controle, a inspeção e a fiscalização de agrotóxicos, seus componentes e afins, e dá outras providências. Diário Oficial da União, Brasília (1989 jul. 12). 4. Machi AR, Ferrari L, Mendes A, Arthur V. Effects of gamma radiation (60Co) on herbicide 2,4-D in control of dayflower (Commelina virginica.L). Rev Verde. 2014;9(3):258-62. 5. Faria NMX, Fassa AG, Facchini LA. Pesticides poisoning in Brazil: the official notification systemand challenges to conducting epidemiological studies. Ciênc Saude Coletiva. 2007;12(1):25-38. 6. Rigotto RM, Vasconcelos DP, Rocha MM. Pesticide use in Brazil and problems for public health. Cad Saude Publica. 2014;30(7):1360-2. 7. Domingues MR, Bernardi MR, Ono EYS, Ono MA. Pesticides: Risk to Rural Worker Health. Semina: Ciências Biológicas e da Saúde. 2004;25(1):45-54. 8. Mannetje A, Eng A, Walls C, Dryson E, McLean D, Kogevinas M, et al. Serumconcentrations of chlorinated dibenzo-p-dioxins, furans and PCBs, among former phenoxy herbicide production workers and firefighters in New Zealand. Int Arch Occup Environ Health. 2016;89(2):307-18. 9. Silver SR, Bertke SJ, Hines CJ, Alavanja MC, Hoppin JA, Lubin JH, et al. Cancer incidence and metolachlor use in the Agricultural Health Study: An update. Int. J. Cancer. 2015;137(11): 2630-43. 10. Evangelou E, Ntritsos G, Chondrogiorgi M, Kavvoura FK, Hernández AF, Ntzani EE, et al. Exposure to pesticides and diabetes: a systematic review and meta-analysis. Environ. Int. 2016 May;91:60-8. 11. Mostafalou S, Abdollahi M. Pesticides and human chronic diseases: Evidences, mechanisms, and perspectives. Toxicol. Appl. Pharmacol. 2013;268(2):157-77. 12. Vasilaki F, Tsitsimpikou C, Tsarouhas K, Germanakis I, Tzardi M, Kavvalakis M, et al. Cardiotoxicity in rabbits after long-termnandrolone decanoate administration. Toxicol Lett. 2016;241:143-151. 13. Malaspina FG, Zinilise ML, Bueno PC. Epidemiologic profile of the pesticides intoxication in Brazil, in the period 1995 to 2010. Cad. Saude Colet. 2011;19(4):425-34. 14. Oliveira NP, Moi GP, Atanaka-Santos M, Silva AMC, Pignati WA. Congenital defects in the cities with high use of pesticides in the state of Mato Grosso, Brazil. Ciênc. Saúde coletiva. 2014;19(10):4123-30. 15. Brasil. Ministério da Saúde. Define as terminologias adotadas em legislação nacional, conforme o disposto no Regulamento Sanitário Internacional 2005 (RSI 2005), a relação de doenças, agravos e eventos em saúde pública de notificação compulsória em todo o território nacional e estabelece fluxo, critérios, responsabilidades e atribuições aos profissionais e serviços de saúde. Portaria n. 104, 25 de janeiro 2011. 16. Abdolghaffari AH, Baghaei A, Solgi R, Gooshe M, Baeeri M, Nigjeh N, et al. Molecular and biochemical evidences on the protective effects of Triiodothyronine against phosphine-induced cardiac andmitochondrial toxicity. Life Sci. 2015 Oct 15;139:30-9. 17. AmaraI IB, Soudani N, Hakim A, Troudi A, Zeghal KM, Boudawara T, et al. Protective effects of vitamin E and selenium against dimethoate- induced cardiotoxicity in vivo: biochemical and histological studies. Environ Toxicol. 2013;28(11):630-43. 18. Solgi R, Baghaei A, Golaghaei A, Hasani S, Baeeri M, Navaei M, et al. Electrophysiological and molecular mechanisms of protection by iron sucrose against phosphine-induced cardiotoxicity: a time course study. Toxicol Mech Methods. 2015;25(4):249-57. 19. DhivyaVadhanaMS, SivaArumugamS, Carloni M, Nasuti C, Gabbianelli R. Early life permethrin treatment leads to long-term cardiotoxicity. Chemosphere. 2013;93(6):1029-34. 20. Myers JP, Antoniou MN, Blumberg B, Carroll L, Colborn T, Everett LG, et al. Concerns over use of glyphosate-based herbicides and risk associated with exposures: a consensus statement. Environ Health. 2016 Feb 17;15:19. 21. Oliveira Júnior SA, Padovani CR, Rodrigues SA, Silva NR, Martinez PF, Campos DHS, et al. Extensive impact of saturated fatty acids onmetabolic and cardiovascular profile in rats with diet-induced obesity: a canonical analysis. Cardiovasc Diabetol. 2013 Apr 15;12:65. 22. Matsubara LS, Matsubara BB, Okoshi MP, Cicogna AC, JanickiJS. Alterations in myocardial collagen content affect rat papillary muscle function. Am J Physiol Heart Circ Physiol. 2000;279(4):H1534-9. 23. Huet E, Gabison E, Vallee B, Mougenot N, Linguet G, Riou B, et al. Deletion of extracellular matrix metalloproteinase inducer/CD147 induces altered cardiac extracellular matrix remodeling in aging mice. J Physiol Pharmacol. 2015;66(3):355-66. 24. Friedrich K. Avaliação dos efeitos tóxicos sobre o sistema reprodutivo, hormonal e câncer para seres humanos após o uso do herbicida 2,4D. [tese]. Rio de Janeiro: FIOCRUZ, Instituto Nacional de Controle de Qualidade em Saúde; 2014. 25. Azevedo PS, Polegato BF, Minicucci MF, Paiva SA, Zornoff LA. Cardiac Remodeling: Concepts, Clinical Impact, Pathophysiological Mechanisms and Pharmacologic Treatment. Arq Bras Cardiol. 2016;106(1):e62-9. 26. Razavi BM, Hosseinzadeh H, Movassaghi AR, Imenshahidi M, Abnous K. Protective effect of crocin on diazinon induced cardiotoxicity in rats in subchronic exposure. Chem Biol Interact. 2013;203(3):547-55. 27. Maciel RA. Study of the effects of deltamethrin in the stimulation and cardiac conduction and in the response to oxidative stress in wistar rats. [tese]. Campinas: UNICAMP, Faculdade de Engenharia de Alimentos; 2011. 28. Münzel T, Gori T, Keaney JF Jr, Maack C, Daiber A. Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications. Eur. Heart J. 2015;36(38):2555-64. 29. Moreira RD, Moriel AR, Murta Junior LO, Neves LA, GodoyMF. Fractal dimension in quantifying the degree of myocardial cellular rejection after cardiac transplantation. Rev Bras Circ Cardiovasc. 2011;26(2):155-63. 30. Tambasco M, Costello BM, Kouznetsov A, Yau A, Magliocco AM. Quantifying the architectural complexity of microscopic images of histology specimens. Micron. 2009;40(4):486-94. 31. Brasil. Presidência da República, Subchefia para Assuntos Jurídicos. Lei n. 5.889 de 8 de Junho de 1973. Estatui Normas Reguladoras do Trabalho Rural e Dá Outras Providências. Diário Oficial da União, Brasília(1973 jun 11); Sec.1:5585. 32. Judai MA, Antunes PA. Ototoxicidade em trabalhadores por exposição a agrotóxicos. IX Fórum Ambiental da Alta Paulista. 2013;9(11):177-85. 33. Pacagnelli FL, Sabela AKDA, Mariano TB, Ozaki GAT, Castoldi RC, Carmo EM, et al. Fractal Dimension in Quantifying Experimental- Pulmonary- Hypertension-Induced Cardiac Dysfunction in Rats. Arq Bras Cardiol. 2016;107(1):33-9. Negrão et al. Effect of herbicide 2,4D inhalation on cardiac remodeling Int J Cardiovasc Sci. 2019;32(3)247-252 Original Article This is an open-access article distributed under the terms of the Creative Commons Attribution License

RkJQdWJsaXNoZXIy MjM4Mjg=