IJCS | Volume 32, Nº2, May/June 2019

216 12. Araújo CC, Leon LL. Biological activities of Curcuma longa L. Mem Inst Oswaldo Cruz. 2001;96(5):723-8. 13. Toda S, Miyase T, Arichi H, Tanizawa H, Takino Y. Natural antioxidants. III. Antioxidative components isolated from rhizome of Curcuma longa L. Chem Pharm Bull. 1985;33(4):1725-8. 14. Apisariyakul A, Vanittanakom N, Buddhasukh D. Antifungal activity of turmeric oil extracted from Curcuma longa (Zingiberaceae). J Ethnopharmacol. 1995;49(3):163-9. 15. Adamayore OA, Anjos RM, Almeida MM, Veras RC, Silvia DF, Oliveira FA, et al. Hypotensive and endothelium-independent vasorelaxant effects of methanolic extract from Curcuma longa L. in rats. J Ethnopharmacol. 2009;124(3):457-62. 16. Organization for Economic Co-operation and Development (OECD). Acute Oral Toxicity- Acute Toxic Class Method. Eleventh Addendum to the OECD guidelines for the testing of chemicals. Paris; 2001. 17. MaloneMH, Robichaud RC. A hippocratic screen for pure or crude drug materials. Lloydia. 1962;25(4):320-32. 18. Ceballos G; Gutiérrez-Salmeán G, Meaney E. The vascular endothelium: a review series I. Basic aspects of the vascular endothelium. Rev Mex Cardiol. 2015;26(2):95-100. 19. PintoWJ, Areas MA, Reyes FGR. Óxido nítrico e o sistema vascular: uma revisão. Acta Cient Biol Saúde. 2003;5(1):47-61. 20. Batlouni M. Endotélio e hipertensão arterial. Rev. Bras. Hipertens. 2001;8(3):328-38. 21. Dusse LMS, Vieira LM, CarvalhoMG. Revisão sobre óxido nítrico. J Bras Patol Med Lab. 2003;39(4):435-50. 22. Jeddi S, Asl AN, Asgari A, Ghasemi A.The effect of sleep deprivation on cardiac function and tolerance to ischemia-reperfusion injury in male rats. Arq Bras Cardiol. 2016;106(1):41-8. 23. Potje SR. Efeito vasorelaxante do doador de óxido nítrico [Ru (terpy)(bdq) NO] 3+(TERPY) em artéria de resistência e sua interação com a óxido nítrico sintase endotelial (eNOS) de ratos espontaneamente hipertensos (SHR) [Tese]. Araçatuba (SP): Universidade Estadual Paulista Julio de Mesquita ; 2016. 24. Cabral JE, Belik J. Persistent pulmonary hypertension of the newborn: recent advances in pathophysiology and treatment. J Pediatr. 2013;89(3):226-42. 25. Flora Filho R, Zilberstein B. Óxido nítrico: o simples mensageiro percorrendo a complexidade. Metabolismo, síntese e funções. Rev Assoc Med Bras. 2000;46(3):265-71. 26. Maggi C A, Barbanti G, Turini, D, Giuliani S. Effect of NG-monomethyl L-arginine (L-NMMA) and NG-nitro L-arginine (L-NOARG) on non- adrenergic non-cholinergic relaxation in the circular muscle of the human ileum. Br J Pharmacol. 1991;103(4):1970-2. 27. Batlouni M. Nonsteroidal anti-inflammatory drugs: cardiovascular, cerebrovascular and renal effects. Arq Bras Cardiol. 2010;94(4);556-63. 28. Andre E. Análise dos mecanismos envolvidos no relaxamento induzido pelo sesquiterpeno poligodial em vasos de coelho e cobaia e no corpo cavernoso de coelho in vitro [Dissertação]. Florianópolis (SC): Universidade Federal de Santa Catarina; 2000. 29. Rodwell VW, Bender DA, Botham KM, Kennelly PJ, Weil PA. Harper’s illustrate biochemistry. 30th ed. New York: McGraw Hill Global; 2015. 30. Rodrigues LU, Soares CT, Venuto D.B, Santana RG, Xavier AR, Silva Junior CT, et al. Muscarinic receptors and chronic obstructive pulmonary disease: from biology to clinical practice. Rev Med. 2016;95(3):128-32. 31. Vieira AM. Eficácia do extrato aquoso de maytenus rigida mart. (celastraceae) na lesão gástrica induzida por etanol em camundongos: análise do envolvimento de óxido nítrico, prostaglandinas, receptores opioides e α -2-adrenérgicos [Dissertação]. Sobral (CE): Universidade Federal do Ceará; 2013. 32. Golan DE, Tashjian AH, Armstrong EJ, Armstrong AW. Princípios de farmacologia: a base fisiopatológica da farmacoterapia. 2a ed. Rio de Janeiro: Guanabara Koogan; 2009. 33. VelosoCC,SoaresGL,PerezAC,RodriguesVG,SilvaFC.Pharmacological potential of Maytenus species and isolated constituents, especially tingenone, for treatment of painful inflammatory diseases. Rev Bras Farmacogn. 2017;27(4):533-40. 34. Chioca LR, Segura RCF, Andreatini R, Losso EM. Antidepressants and local anesthetics: drug interactions of interest to dentistry. Rev Sul-Bras Odontol. 2010;7(4):466-73. 35-Silva AS, Zanesco A. Physical exercise, ß-adrenergic receptors, and vascular response. J Vasc Bras. 2010;9(2):47-56. 36. Kuriyama H, Kitamura K, Nabata H. Pharmacological and physiological significance of ion channels and factors that modulate them in vascular tissues. Pharmacol Rev. 1997;47(3):387-573. 37. Faraci FM, Heistad DD. Regulation of the cerebral circulation: role of endothelium and potassium channels. Physiol Rev. 1998;78(1):53-97. Brozzo et al. Curcuma longa abolishes contractions in the aortic artery Int J Cardiovasc Sci. 2019;32(3)207-216 Original Article This is an open-access article distributed under the terms of the Creative Commons Attribution License