IJCS | Volume 32, Nº2, May/June 2019

215 1. Organização Pan-Americana de Saúde. (OPAS). Doenças Cardiovasculares. Brasília (DF);2016. [citado 19 out. 2018]. Disponível em: https://www.paho.org/bra/index.php?option=com_content&vie w=article&id=5253:doencas-cardiovasculares&Itemid=839. 2. Braga ADA, Barleta VCN. Alimento funcional: uma nova abordagem terapêutica das dislipidemias como prevenção da doença aterosclerótica. Cadernos UniFOA. 2007;2(3). [citado 19 out. 2018]. Disponível em: https://www.unifoa.edu.br/pesquisa/caderno/ edicao/03/100.pdf. 3. Oliveira GMM, Mendes M, Malachias MVB, Morais J, Filho OM, Coelho AS, et al. 2017 Guidelines for the management of arterial hypertension in primary health care in portuguese-speaking countries. Rev Port Cardiol. 2017;36(11):789-98. 4. Fonteneles JL, Santos ZMSA, Silva MP. Estilo de vida de idosos hipertensos institucionalizados: análise com foco na educação em saúde. Revista da Rede de Enfermagem do Nordeste. RENE. 2009;10(3):53-60. 5. Martelli A, LongoMAT, Seriane C. Clinical aspects and actionmechanism of main pharmacological classes used in the treatment of hypertension. Estud Biol. 2008;30(70/71/72):149-56. 6. Barbosa MO, Lacerda GM, Alves DA, Oliveira CJ, Kerntopf MR, Fernandes GP. Use of natural resources for the treatment of diabetes and hypertension in traditional communities. R Interd. 2017;10(2):125-31. 7. Souza JBP, Ataliba FJB, Costa DA, Farias, AD. Interações plantamedicinal x medicamento convencional no tratamento da hipertensão arterial. Infarma Ciências Farmacêuticas. 2017;29(2):90-9. 8. Chainani-Wu N. Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa). J Altern Complement Med. 2003;9(1):161-8. 9. Pintão AM, Silva IF. A verdade sobre o açafrão. In: Workshop Plantas Medicinais e Fitoterapêuticas nos Trópicos; 29-31 out 2008; Portugal. Portugal: IICT/CCCM; 2008. p. 1-19. 10. Ghorbanzadeh V, Mohammadi M, DariushnejadH, Abhari A, Chodari L, Mohaddes G. Cardioprotective effect of crocin combinedwith voluntary exercise in rat: role of Mir-126 and Mir-210 in heart angiogenesis. Arq Bras Cardiol. 2017;109(1):54-62. 11. Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern Med Rev. 2009;14(2):141-53. References Brozzo et al. Curcuma longa abolishes contractions in the aortic artery Int J Cardiovasc Sci. 2019;32(3)207-216 Original Article Conclusion The AECL induced an important vasorelaxant effect, beingmore significant in the presence of the endothelium. The muscarinic pathway seems to be the main one involved with this effect, followed by the NO production pathway, the Prostacyclin’s. The opening of K + channels by the AECL, although with a prominently lower degree of participation when compared to the retro-reported pathways, seems to have greater expression than its blockade toVOCCs. AECL showed no evidence of toxicity at the administered concentrations. Further studies are needed on the phytochemistry of AECL, as well as better pharmacological investigation through many other approaches and experimental models, including the use of tools to elucidate the action mechanisms of the extract. Acknowledgments We would like to thank Conselho Nacional de Desenvolvimento Científico e Tecnológico for providing financial support to the project (CNPQ - CNPQ - 407943 / 2013-7). Brozzo, NPM is supported by a scholarship from CAPES. Author´s contribution StudyProject andDesignandwritingof themanuscript: Brozzo NPM; data acquisition and Critical review of the manuscript regarding important intellectual content: BrozzoNPM, Cunha RM, Meneguetti DUO. Data analysis and interpretation: Brozzo NPM, Cunha RM, Silva EF, Silva DA. Statistical analysis: Brozzo NPM, Gonçalves EA. Financial support provision: Cunha RM. Potential Conflict of Interest No potential conflict of interest relevant to this article was reported. Sources of Funding This study was partially funded by CNPq. Study Association This article is part of the thesis of master submitted by Natacha Pinheiro Melo Brozzo, from Universidade Federal do Acre . Ethics approval and consent to participate This study was approved by the Ethics Committee on Animal Experiments of the Universidade Federal do Acre under the protocol number 23107.018498.

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