IJCS | Volume 32, Nº2, May/June 2019

211 Figure 1 - Concentration-response curve for CLAE (1, 3, 10, 30, 100, 300 and 1000 µg/mL) on PHE-induced contractions (0.1 μM) in isolated aortic annuli of normotensive rats in the presence and absence of functional endothelium. The dots represent the mean ± SD of the concentrations used with n = 6 and **(p < 0.01) versus E + . % RELAXATION AECL Present endothelium (EC 50 = 4.32 ± 0.05 µg/mL) Absent endothelium** (EC 50 = 134.20 ± 1.80 µg/mL) Figure 2 - Concentration-response curve for CLAE (1, 3, 10, 30, 100, 300 and 1000 µg/mL) in rat isolated thoracic aorta annulus with intact endothelium and pre-contracted with PHE (0.1 μM) before E + and after NO synthase inhibition. The dots represent the mean ± SD of the concentrations used with n = 6 and **(p < 0.01) versus E + . % RELAXATION AECL Present endothelium (EC 50 = 4.32 ± 0.05 µg/mL) After L-NAME (EC 50 = 126.50 ± 2.35 µg/mL) Brozzo et al. Curcuma longa abolishes contractions in the aortic artery Int J Cardiovasc Sci. 2019;32(3)207-216 Original Article