IJCS | Volume 31, Nº6, November / December 2018

DOI: 10.5935/2359-4802.20180062 630 ORIGINAL ARTICLE International Journal of Cardiovascular Sciences. 2018;31(6)630-642 Mailing Address: Alex dos Santos Felix Rua das Laranjeiras, 374. Postal Code: 22240-004, Laranjeiras, Rio de Janeiro, RJ - Brazil. E-mail: alex.felix.ext@dasamed.com.br , alexsfelix@gmail.com.br Echocardiographic Assessment of Right Ventricular Function by Two-Dimensional Strain In Patients with Left-Sided Valvular Heart Disease: Comparison with Three- Dimensional Echocardiography Alex dos Santos Felix, 1 Ana Paula dos Reis Velloso Siciliano, 1 Luciano Herman Juacaba Belém, 1 Fabiula Schwartz de Azevedo, 1 Sergio Salles Xavier, 2 Andrea Rocha De Lorenzo, 1 Clerio Francisco de Azevedo Filho 1 Instituto Nacional de Cardiologia (INC), 1 RJ - Brazil Fundação Oswaldo Cruz (FIOCRUZ), 2 RJ - Brazil Manuscript received November 07, 2017, revised manuscript March 27, 2018, accepted May 14, 2018. Abstract Background: Right ventricular (RV) dysfunction is a well-known predictor of mortality in patients with valvular heart disease (VHD). The assessment of RV function is often difficult due to complex geometry and hemodynamic factors. Objective: We aim to analyze RV function in patients with severe mitral and/or aortic valve disease using two- dimensional strain (2DS) imaging and conventional echocardiographic parameters, comparing it with right ventricular ejection fraction (RVEF) measured by three-dimensional echocardiography (3DE). Methods: Fifty-three patients with severe mitral and/or aortic VHD underwent complete transthoracic echocardiogram in the preoperative setting for cardiac surgery, including conventional echocardiographic parameters of RV function and speckle-tracking derived 2DS indices: RV global longitudinal strain (RVGS) and RV free wall longitudinal strain (RVFWS). Conventional echocardiographic and 2DS parameters were compared with real-time 3DE RVEF using Spearman correlation test. For comparison between two groups of patients based on the presence of RV dysfunction (normal RVEF ≥ 44% - A, abnormal RVEF < 44% - B), we used nonparametric Mann-Whitney U test. ROC (receiver operating characteristic) curve analysis was used to assess the clinical utility of all RV function variables in defining RV dysfunction. P values <0,05 were considered statistically significant. Results: We found a significant correlation between all parameters and RVEF (p<0.05), with best results for RV fractional area change (FAC), RVGS, and RVFWS. Dividing the population into two-groups based on RVEF, we found 14 patients with RV dysfunction (27.4%), and significant differences between the groups for all RV function variables. For detection of RV dysfunction defined by 3DE, ROC curve analysis showed the best area under the curve (AUC) for RVGS (0.872), RVFWS (0.851) and FAC (0.932). Conclusions: We observed significant correlation between RVGS, RVFWS and RVEF, with good accuracy in detecting RV dysfunction, comparable to FAC and better than other conventional parameters of RV function assessment. The evaluation of RVmyocardial deformation with 2DS may have additional diagnostic and prognostic value in patients with severe left-sided VHD. (Int J Cardiovasc Sci. 2018;31(6)630-642) Keywords: Ventricular Dysfunction, Right/diagnostic, imaging; Ventricular Dysfunction, Right/physiopathology; Echocardiography, Tridimensional/methods; Stroke Volume; Valvular Heart Diseases; Prognosis. Introduction The accurate assessment of right ventricular (RV) systolic function plays an important role for the evaluation, follow-up and treatment of a myriad of cardiac and non-cardiac diseases. 1-4 The assessment of RV function by conventional echocardiographic parameters has major challenges, and its accuracy is limited by the irregular geometry of the RV chamber, the distinct pattern of contractility (mostly based on longitudinal deformation), the trabeculated inner contour of the cavity with poor endocardial border definition, separate