IJCS | Volume 31, Nº5, September / October 2018

488 Figure 2 - Mean time in therapeutic range (TTR) according to SAMe-TT 2 R 2 score (p = 0.593 - non-paired Student t test). Bars represent 95% confidence intervals. Pivatto Júnior et al. SAMe-TT 2 R 2 score forVTE patients? Int J Cardiovasc Sci. 2018;31(5)483-491 Original Article Table 2 - Adverse events during anticoagulation according to the SAMe-TT 2 R 2 score Type of event n Incidence rate (/100 patient- years) Patients with event (n = 111) SAMe-TT 2 R 2 score p (0-1 vs. ≥ 2) 0-1 ≥ 2 DVT 11 2.5 11 (9.9) 6 (13.3) 5 (7.6) 0.348 † PE 2 0.5 2 (1.8) 1 (2.2) 1 (1.5) 1.0 † Major bleeding 11 2.5 11 (9.9) 7 (15.6) 4 (6.1) 0.117 † Death 6 1.4 6 (5.4) 2 (4.4) 4 (6.1) 1.0 † Any event 30 6.8 26 (23.4)* 14 (31.1) 12 (18.2) 0.177 ‡ DVT: deep vein thrombosis; PE: pulmonary embolism; (*) 4 (3.6%) patients had 2 events during follow-up. Data are presented as number (%). † Fisher exact test; ‡ Chi-square test. K intake, treatment interruptions, hepatic dysfunction, mucositis, diarrhea, and the hypercoagulable state induced by cancer itself. An important methodological aspect of the assessment of the SAMe-TT 2 R 2 score is the use of ROC curve analysis, which provides the best statistical method to assess the diagnostic accuracy of a test that has a continuous spectrum of test results. 31 The AUC, also known as c-statistic or c-index, 31 is an effective and combined measure of sensitivity and specificity that describes the inherent validity of diagnostic tests. The AUC can be interpreted as the probability that a randomly selected diseased individual will be rated or ranked as more likely to be diseased (in our study, with a TTR ≥ 65%) than a randomly selected non-diseased individual. 32 In previous studies assessing the SAMe-TT 2 R 2 score in