IJCS | Volume 31, Nº4, July / August 2018

387 Borges et al. Adherence score Int J Cardiovasc Sci. 2018;31(4)383-392 Original Article Table 3 - Logistic regression model reduced by stepwise selection Variables Category B-Coefficient OR [95%CI] p-value Age/years A -0.006 0.994 [0.975 - 1.014] 0.569 Sex A -0.243 0.784 [0.456 - 1.347] 0.378 Family income A 0.855 2.352 [1.161 - 4.765] 0.018 Inadequate use of medication A 3.765 43.183 [19.575 - 95.262] < 0.001 Invasive procedure A 1.619 5.047 [1.015 - 25.107] 0.048 Drug-drug interaction A 4.221 68.095 [25.306 - 183.234] < 0.001 Eating habits A 2.822 16.805 [3.291 - 85.810] 0.001 Clinical conditions A 1.649 5.202 [2.265 - 11.943] < 0.001 Other factors A 2.502 12.206 [6.016 - 24.763] < 0.001 Constant ------- -14.328 ------- ------- OR: odds ratio; 95%CI: 95% confidence interval. Figure 1 - Simonetti medication adherence score. impaired warfarinmetabolism (amiodarone, rifampicin, simvastatin, gemfibrozil), and impaired vitamin K metabolism (acetaminophen). 9 In general, drug interactions reduce the therapeutic effects of OACs and increase the risk for clotting or potentiate such effects and increase the risk of bleeding. Some factors, however, should be considered 9 when the effects of OACs are decreased, such as inhibition