IJCS | Volume 31, Nº3, May/ June 2018

DOI: 10.5935/2359-4802.20180014 218 ORIGINAL ARTICLE International Journal of Cardiovascular Sciences. 2018;31(3)218-225 Mailing Address: Monique Rodrigues Cardoso Rua Náutico, número 112, bloco A2, apto 13. Postal code: 79112-205, Panamá, Campo Grande, Mato Grosso do Sul, MS - Brazil E-mail: cardoso_monique@yahoo.com.br Correlation Between the Complexity of Coronary Lesions and High-Sensitivity Troponin Levels in Patients with Acute Coronary Syndrome Monique Rodrigues Cardoso, Delcio Gonçalves da Silva Junior, Eduardo Alves Ribeiro, AlfredoMoreira da Rocha Neto Universidade Federal do Mato Grosso do Sul (UFMS), Campo Grande, MS - Brazil Manuscript received June 18, 2017; revised manuscript September 21, 2017; accepted September 22, 2017. Abstract Background: Cardiovascular diseases are the leading cause of death in Brazil. Biochemical markers have diagnostic and prognostic importance in acute coronary syndromes (ACSs), with troponin as the preferred biomarker. Studies have already demonstrated a positive relationship between increased levels of high-sensitivity troponin (hsTn) and prognosis. However, few studies have correlated hsTn levels with the complexity of coronary lesions. Objectives: To compare hsTn levels with the complexity of coronary lesions according to the SYNTAX score, and to correlate the levels of this biomarker with the TIMI and GRACE scores in patients with ACS. Methods: Retrospective, cross-sectional study with 174 patients with ACS. The correlation between variables was assessed by the nonparametric Spearman's rank correlation, and statistical analysis was performed by the SPSS program, with a significance level of 5%. Results: Mean age was 63 years, and most patients were women (52.9%), hypertensive, non-diabetic and non- smokers. Nineteen percent of the patients had STEMI, 43.1% NSTEMI, and 36.8% unstable angina. Most were in Killip 1 (82.8%). Median hsTn was 67 pg/mL. Median risk scores were 3, 121 and 3 in the TIMI, GRACE and SYNTAX scores, respectively. There was a correlation of hsTn with SYNTAX (p <0.001, r = 0.440), TIMI (p < 0.001, r = 0.267) and GRACE (p = 0.001, r = 0.261) scores. Conclusion: A positive linear correlation was found of hsTn levels with the complexity of coronary lesions, and with the TIMI and GRACE clinical scores. (International Journal of Cardiovascular Sciences. 2018;31(3)218-225) Keywords: Acute Coronary Syndrome; Troponin; Cardiovascular Diseases / Mortality; Myocardial Infarction; Hospitalization / Economy. Introduction Cardiovascular diseases (CVDs) are the main cause of death in Brazil, generating high costs of hospitalizations every year. 1 According to the World Health Organization, there were 214.2 deaths per 100,000 inhabitants from CVDs in Brazil in 2012, with higher prevalence among men. 2 Acute myocardial infarction (AMI) is one of the main causes of death and disability worldwide. 3 According to the third international definition of AMI, published in 2012, AMI occurs when there is evidence of myocardial necrosis in a clinical context of acutemyocardial ischemia. The importance of biochemical markers in both diagnosis and prognosis of acute coronary syndromes (ACSs) has beenwell documented. 4 Cardiac troponin has been considered the best biomarker for AMI diagnosis since 2000, when a redefinition of myocardial infarction was published. 5 High-sensitivity troponin (hsTn) assay, as comparedwith the first generations of troponin assays,