IJCS | Volume 31, Nº3, May/ June 2018

299 Martucheli et al. Cystatin C and acute coronary syndromes International Journal of Cardiovascular Sciences. 2018;31(3)290-307 Review Article Fu et al., 2013 18 1 st quartile (< 1.23 mg/L) 2 nd quartile (1.23-1.43 mg/L) 3 rd quartile (1.44-1.82 mg/L) 4 th quartile (1.83-5.12 mg/L) NA Risk of all-cause mortality: Univariate analysis: 2 nd quartile x 1 st quartile: OR = 1.31 (1.23-1.43) 3 rd quartile x 1 st quartile: OR = 1.59 (1.44-1.82) 4 th quartile x 1 st quartile: OR = 2.23 (1.83-5.12) p = 0.0001 Akgul et al., 2013 19 1 st and 2 nd tertile (≤ 1.12 mg/L) 3 rd tertile (> 1.12 mg/L) Age; female sex; DM; hypertension; current smoking; Killip class > 1; anemia at admission; KF; lesion in three cardiac vessels; unsuccessful PCI; LVEF < 40%; use of tirofiban; serum creatinine > 1.5 mg/dL. Proportion of patients who developed cardiovascular events: 21.4% (3 rd tertile) x 8.5% (1 st and 2 nd tertile). p < 0.001 Risk of cardiovascular death: Univariate analysis: 3 rd tertile x 1 st and 2 nd tertiles: OR = 5.9 (2.6-13.3). p < 0.001 Multivariate analysis: 3 rd tertile x 1 st and 2 nd tertiles: OR = 4.66 (1.3-16.6). p = 0.017 Widera et al., 2013 20 Without classification NA Risk of cardiovascular event or all-cause mortality: Univariate analysis: Log (cystatin C): OR = 1.9 (1.6-2.3) Manzano -Fernández et al., 2012 21 1 st quartile (< 0.79 mg/L) 2 nd quartile (0.79-0.91 mg/L) 3 rd quartile (0.92-1.13 mg/L) 4 th quartile (1.14-2.55 mg/L) BTP; serum cystatin C; serum creatinine; GFR; hemoglobin, anterior acute coronary syndrome without ST-segment elevation; GRACE risk score. Risk of all-cause mortality Univariate analysis: 2 nd quartile x 1 st quartile: OR = 1.89 (0.35-10.3) 3 rd quartile x 1 st quartile: OR = 2.41 (0.47-12.4) 4 th quartile x 1 st quartile: OR = 7.87 (1.78-34.9) p = 0.004 Multivariate analysis: 2 nd quartile x 1 st quartile: OR = 1.85 (0.34-10.1) 3 rd quartile x 1 st quartile: OR = 1.98 (0.38-10.4) 4 th quartile x 1 st quartile: OR = 6.32 (1.40-28.6) p = 0.014 Ristiniemi et al., 2012 22 1 st tertile (< 0.96 mg/L) 2 nd tertile (0.96-1.21mg/L) 3 rd tertile (> 1.21 mg/L) Age > 65 years; BMI (median > 27,1 kg/m 2 ); sex; CHF; hypertension; previous MI; current smoking; DM; family history of CVD All-cause mortality rate: 18% (3 rd tertile) x 10% (2 nd tertile) x 4% (1 st tertile). p < 0.012 Proportion of cardiovascular events: 35% (3 rd tertile) x 20% (2 nd tertile) x 12% (1 st tertile). p < 0.0012 (3 rd tertile x 1 st tertile) Risk of all-cause mortality: Univariate analysis: 3 rd tertile x 1 st tertile: OR = 2.19 (1.27-3.77). p = 0.0046 Multivariate analysis 3 rd tertile x 1 st tertile: OR = 2.19 (1.28-3.78). p = 0.0046 Risk of cardiovascular events: Univariate analysis: 3 rd tertile x 1 st tertile: OR= 1.86 (1.31-2.65). p = 0.0005 Multivariate analysis 3 rd tertile x 1 st tertile OR = 1.75 (1.22-2.51). p = 0.0024