IJCS | Volume 31, Nº3, May/ June 2018

296 Cont. Table 1 - Characteristics of the selected studies Author/ Year Type of acute coronary syndrome Diagnostic method for acute coronary syndrome Number of patients / Age range (years) Time of follow- up / Outcome measure Method of cystatin C measurement Inclusion of patients with normal kidney function only GFR of patients (mL/ min/1,73m 2 ) or serum creatinine Taglieri et al., 2010 6 NSTEMI Chest pain and at least one of the following criteria: signs of myocardial ischemia in ECG; increased cardiac markers; history of CAD 525/ 58 (50-66) (1 st quartile) 63 (53-70) (2 nd quartile) 68 (59-74) (3 rd quartile) 72 (67-67) (4 th quartile) 12 months/ Cardiovascular death, non-fatal infarction, unstable angina Immunonephelometry No GFR = 92.3 (80.2- 107.4) (1 st quartile) GFR = 84.0 (74.9- 97.3) (2 nd quartile) GFR = 75.1(62.6- 89.8) (3 rd quartile) GFR = 59.1(47.5- 72.9) (4 th quartile) p < 0.001 (4 th quartile x 1 st , 2 nd and 3 rd quartile) Derzhko et al., 2009 26 STEMI Chest pain > 20 min, ST segment elevation in ECG, increased cardiac troponin 150/ 56.99 ± 11.3 6 months/ CHF, non-fatal infarction, unstable angina, all-cause mortality Immunonephelometry No Serum creatinine (mg/dL) (general) = 1.02 ± 0.17 Ichimoto et al., 2009 7 STEMI Chest pain > 30 min, ST segment elevation in ECG, CK-MB levels twice greater than upper normal limit 71/ 61.9 ± 10.4 (cystatin C < 0.96 mg/L) 66.5 ± 12.6 (cystatin C ≥ 0.96 mg/L) Approximately 6 months/ All-cause mortality, non-fatal infarction, need of revascularization, stroke, CHF Immunoturbidimetry No Serum creatinine (mg/dL) = 0,93 ± 0,22 (cystatin C ≥ 0,96 mg/L) Serum creatinine (mg/dL) = 0,72 ± 0,14 (cystatin C < 0,96 mg/L) p < 0,01 Kilic et al., 2009 27 Unstable angina, NSTEMI, STEMI Increased cardiac markers and at least one of these criteria: chest pain; development of pathological Q waves in ECG; signs of ischemia in ECG; PCI; pathological findings of AMI 160/ 59 ± 10 (without cardiovascular events) 61 ± 10 (with cardiovascular events) 12 months/ Cardiovascular death, non- fatal infarction, recurrent angina Immunoenzymatic assay Yes GFR = 80 ± 31 (with cardiac events) GFR = 92 ± 35 (without cardiac events) p = 0,03 Martucheli et al. Cystatin C and acute coronary syndromes International Journal of Cardiovascular Sciences. 2018;31(3)290-307 Review Article